抑制性检查点分子是免疫细胞表面的一类受体，通过传递负向信号调节免疫应答强度，防止过度激活导致组织损伤。
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| 产品号 | 产品名称 | 蛋白编码 | 图片 |
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| ALP8138 | Q7Z7D3 -1 (F29-A258) |
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| Adamas-life ® B7-H4, also known as B7x and B7S1, is a 50-80 kDa glycosylated member of the B7 family of immunomodulatory proteins.B7-H4 is up-regulated in several carcinomas in correlation with tumor progression and metastasis. A soluble form of B7-H4 is elevated in the serum of ovarian cancer, renal cell carcinoma, and rheumatoid arthritis patients, also in correlation with advanced disease status . | |||
| ALP8130 | Q7Z7D3-1(Phe29-Ala258) |
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| B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount so anti-CD3 stimulation, 2Ig‑B7‑H3 enhances T cell proliferation, T cell interferon-gamma (IFN-gamma) production, and cytotoxic T cells induction. | |||
| ALP8132 |
Recombinant Human B7-H5/Gi24/VISTA Protein,Human,C-His,Expi293 |
Q9H7M9(Phe33-Ala194) |
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| B7-H5, also known as VISTA , B7H5, Dies1, SISP1 and C10orf54, is a 55-65 kDa member of the Ig superfamily. It is a transmembrane molecule expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. | |||
| ALP8194 | O95971(Gly25-Leu158) |
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| CD160 (also Natural killer cell receptor BY55) is a 27 ‑ 30 kDa member of the Ig superfamily. In human, it is expressed principally on nonmyeloid hematopoietic cells. CD160 antigenis a receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells. | |||
| ALP8184 | P15151-1(Trp21-Asn343) |
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| CD155 is a cell surface adhesion molecule functioning in tumor cell migration, invasion, and metastasis, and not surprisingly, is also designated as a common tumor-associated antigen. CD155 is also recognized by NK cells to induce their cytotoxicity. CD155 is also commonly referred to as the "poliovirus receptor," or PVR. | |||
| ALP8187 | P15151-1(Trp21-Asn343) |
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| CD155 is a cell surface adhesion molecule functioning in tumor cell migration, invasion, and metastasis, and not surprisingly, is also designated as a common tumor-associated antigen. CD155 is also recognized by NK cells to induce their cytotoxicity. CD155 is also commonly referred to as the "poliovirus receptor," or PVR. | |||
| ALP8192 | P15151-1(Trp21-Asn343) |
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| CD155 is a cell surface adhesion molecule functioning in tumor cell migration, invasion, and metastasis, and not surprisingly, is also designated as a common tumor-associated antigen. CD155 is also recognized by NK cells to induce their cytotoxicity. CD155 is also commonly referred to as the "poliovirus receptor," or PVR. | |||
| ALP8200 | Q8K094-1(Asp29-Leu348) |
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| CD155 is a cell surface adhesion molecule functioning in tumor cell migration, invasion, and metastasis, and not surprisingly, is also designated as a common tumor-associated antigen. CD155 is also recognized by NK cells to induce their cytotoxicity. CD155 is also commonly referred to as the "poliovirus receptor," or PVR. | |||
| ALP8271 | P21589-1(Trp27-Lys547) |
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| CD73, also known as ecto-5'-nucleotidase, is an enzyme that in humans is encoded by the NT5E gene.CD73 commonly serves to convert AMP to adenosine.The enzyme consists of a dimer of 2 identical 70-kD subunits bound by a glycosyl phosphatidyl inositol linkage to the external face of the plasma membrane. The enzyme is used as a marker of lymphocyte differentiation. A deficiency of CD73 occurs in a variety of immunodeficiency diseases. | |||
| ALP8262 |
Recombinant Cynomolgus/Rhesus macaque CD47 Protein,Cynomolgus/Rhesus macaque,C-His,Expi293 重组蛋白Cynomolgus/Rhesus macaque CD47 Protein,Cynomolgus/Rhesus macaque,C-His,Expi293 |
F7A802(Gln19-Glu141) |
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| CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα).CD-47 acts as a don't eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers. | |||
| ALP8264 |
Recombinant Cynomolgus CD73/NT5E Protein,Cynomolgus,C-His,Expi293 |
EHH53214.1(Trp27-Cys554) |
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| CD73, also known as ecto-5'-nucleotidase, is an enzyme that in humans is encoded by the NT5E gene.CD73 commonly serves to convert AMP to adenosine.The enzyme consists of a dimer of 2 identical 70-kD subunits bound by a glycosyl phosphatidyl inositol linkage to the external face of the plasma membrane. The enzyme is used as a marker of lymphocyte differentiation. A deficiency of CD73 occurs in a variety of immunodeficiency diseases. | |||
| ALP8265 | Q08722-1(Gln19-Pro139) |
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| CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα).CD-47 acts as a don't eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers. | |||
| ALP8266 | P21589-1(Trp27-Lys547) |
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| CD73, also known as ecto-5'-nucleotidase, is an enzyme that in humans is encoded by the NT5E gene.CD73 commonly serves to convert AMP to adenosine.The enzyme consists of a dimer of 2 identical 70-kD subunits bound by a glycosyl phosphatidyl inositol linkage to the external face of the plasma membrane. The enzyme is used as a marker of lymphocyte differentiation. A deficiency of CD73 occurs in a variety of immunodeficiency diseases. | |||
| ALP8269 | Q08722-1(Gln19-Pro139) |
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| CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα).CD-47 acts as a don't eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers. | |||
| ALP8277 | Q61735-1(Gln19-Lys140) |
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| CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα).CD-47 acts as a don't eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers. | |||
| ALP8278 | Q61503(Trp29-Lys549) |
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| CD73, an ecto-5'-Nucleotidase, is an ectoenzyme expressed by most cell types. The 5'-Nucleotidase activity of CD73 converts extracellular nucleoside‑5'‑monophosphates to nucleosides, with AMP as the preferred substrate. CD73 is one of several enzymes responsible for the production of extracellular adenosine, a signaling molecule that is involved in responses to inflammation and tissue injury. | |||
| ALP8293 | P40200-2(Val22-Met503) |
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| The receptors CD96 and TIGIT are expressed on the surface of T and natural killer (NK) cells, and recent studies suggest both play important inhibitory roles in immune function. CD96 has been shown to modulate immune cell activity in mice, with Cd96-/- mice displaying hypersensitive NK-cell responses to immune challenge and significant tumor resistance. The counterbalance between the putative inhibitory CD96 and TIGIT receptors and the activating receptor, CD226, offers unique strategies for immuno-oncology drug development. | |||
| ALP6838 | Q9BQ51 -1 (L20-P219) |
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| PD-L2 蛋白独立于 PDCD1 运行，在 T 细胞增殖和 IFNG 产生中发挥着至关重要的作用。它与 PDCD1 的相互作用抑制增殖和细胞因子的产生。PD-L2 和 PDCD1 之间的相互作用调节免疫反应，影响 T 细胞的激活和功能。这种分子相互作用增加了控制 T 细胞行为的机制的复杂性，凸显了 PD-L2 在免疫调节中的多功能作用。 | |||
| ALP6688 | P12804 (P197-P432) |
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| FGL2是凝血级联中的关键酶，在凝血酶原向凝血酶的转化中起关键作用，反映了其对止血和凝血过程的重要贡献。在结构上，FGL2 形成以二硫键为特征的同源四聚体，这有助于其在凝血酶生成的复杂过程中的功能完整性和催化活性。 | |||
| ALP8139 | Q9H7M9 (F33-A194) |
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| B7-H5, also known as VISTA , B7H5, Dies1, SISP1 and C10orf54, is a 55-65 kDa member of the Ig superfamily. It is a transmembrane molecule expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. | |||
