激活免疫细胞功能的表面分子，通过传递正向信号增强免疫应答，与抑制性检查点共同调控免疫平衡。
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| 产品号 | 产品名称 | 蛋白编码 | 图片 |
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| ALP8136 | O75144 -1 (D19-S258) |
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| Adamas-life ® B7-H2, also known as B7-related protein (B7RP1), ICOS Ligand, and CD275, is an approximately 60 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. B7-H2 is a ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. | |||
| ALP8128 |
Recombinant Cynomolgus B7-H6/NCR3LG1 Protein,Cynomolgus,C-His,Expi293 重组蛋白Cynomolgus B7-H6/NCR3LG1 Protein,Cynomolgus,C-His,Expi293 |
XP_005578557.1(Asp25-Asp259) |
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| B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount so anti-CD3 stimulation, 2Ig‑B7‑H3 enhances T cell proliferation, T cell interferon-gamma (IFN-gamma) production, and cytotoxic T cells induction. | |||
| ALP8206 | P41217-1(Gln31-Gly232) |
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| CD200 and its receptors are highly expressed in the lung, on epithelial cells and leukocytes, and emerging evidence links dysregulation of the CD200 pathway with asthma. Moreover, pharmacological modulation of CD200 receptors was shown to improve clinical and inflammatory outcomes of preclinical asthma models. | |||
| ALP8209 |
Recombinant Human CD200 R1/CRTR2 Protein,Human,C-hFc,Expi293 |
AAQ19772(Ala27-Leu266) |
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| CD200Fc, a chimeric molecule including the extracellular domain of CD200 and a murine IgG2a Fc region, regulates immune responses following engagement of a cell surface receptor, CD200R, expressed on cells of the myeloid and T cell lineage. A recent report focused attention on a family of CD200Rs, but concluded that only one member used CD200 as its ligand. | |||
| ALP8203 | P41217-1(Gln31-Gly232) |
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| CD200 and its receptors are highly expressed in the lung, on epithelial cells and leukocytes, and emerging evidence links dysregulation of the CD200 pathway with asthma. Moreover, pharmacological modulation of CD200 receptors was shown to improve clinical and inflammatory outcomes of preclinical asthma models. | |||
| ALP8212 |
Recombinant Human CD200 R1/CRTR2 Protein,Human,C-His-Avi,Expi293 |
AAQ19772(Ala27-Leu266) |
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| CD200Fc, a chimeric molecule including the extracellular domain of CD200 and a murine IgG2a Fc region, regulates immune responses following engagement of a cell surface receptor, CD200R, expressed on cells of the myeloid and T cell lineage. A recent report focused attention on a family of CD200Rs, but concluded that only one member used CD200 as its ligand. | |||
| ALP8282 | Q9GKP3(Thr18-Pro153) |
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| CD28 is the receptor for CD80 (B7-1) and CD86 (B7-2) proteins.When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. | |||
| ALP8288 |
重组蛋白Human/Cynomolgus/Rhesus macaque CD28 Protein,Human/Cynomolgus/Rhesus macaque,N-His-Avi,Expi293 |
P10747-1(Asn19-Pro152) |
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| CD28 is the receptor for CD80 (B7-1) and CD86 (B7-2) proteins.When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. | |||
| ALP8286 |
重组蛋白Human/Cynomolgus/Rhesus macaque CD28 Protein,Human/Cynomolgus/Rhesus macaque,N-hFc,Expi293 |
P10747-1(Asn19-Pro152) |
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| CD28 is the receptor for CD80 (B7-1) and CD86 (B7-2) proteins.When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. | |||
| ALP8287 |
重组蛋白Human/Cynomolgus/Rhesus macaque CD28 Protein,Human/Cynomolgus/Rhesus macaque,N-mFc,Expi293 |
P10747-1(Asn19-Pro152) |
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| CD28 is the receptor for CD80 (B7-1) and CD86 (B7-2) proteins.When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. | |||
| ALP8281 | Q9GKP3(Thr18-Pro153) |
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| CD28 is the receptor for CD80 (B7-1) and CD86 (B7-2) proteins.When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. | |||
| ALP6583 |
Cynomolgus B7-1/CD80 Protein, Cynomolgus, HEK293, C-6His 重组蛋白Cynomolgus B7-1/CD80 Protein, Cynomolgus, HEK293, C-6His |
G7NXN7 (V35-N242) |
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| CD80 是一种癌症免疫的共刺激细胞因子，通过结合 CD28 或 CTLA-4 而激活。CD80 低表达时会发生肿瘤免疫逃逸。CD80 受 TP53 诱导表达增加，会刺激抗肿瘤免疫反应。 | |||
| ALP6589 | P10747-1/ Q0PDN3 /Q0PDN4 (N19-P152) |
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| CD28 蛋白对于 T 细胞激活、增强增殖、细胞因子产生和存活至关重要。当与 TCR/CD3 和 CD40L 连接时，CD28 促进 IL4 和 IL10 的产生，从而调节免疫反应。 | |||
| ALP8126 |
Cynomolgus B7-H2/ICOSLG Protein,Cynomolgus,C-His,Expi293 重组蛋白Cynomolgus B7-H2/ICOSLG Protein,Cynomolgus,C-His,Expi293 |
XP_005548617.1 (D19-T256) |
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| B7-H2, also known as B7-related protein (B7RP1), ICOS Ligand, and CD275, is an approximately 60 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. B7-H2 is a ligand for the T- cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. | |||
| ALP8133 | Q68D85 (D25-S262) |
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| B7-H6 is a glycosylated member of the B7 family of immune co ‑ stimulatory proteins. which is a ligand for the NK cell activating receptor NKp30, was targeted to create a CAR that targets multiple tumor types. B7H6 is expressed on various primary human tumors, including leukemia, lymphoma and gastrointestinal stromal tumors, but it is not constitutively expressed on normal tissues. | |||
| ALP8140 | Q68D85 (D25-S262) |
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| B7-H6 is a glycosylated member of the B7 family of immune co ‑ stimulatory proteins. which is a ligand for the NK cell activating receptor NKp30, was targeted to create a CAR that targets multiple tumor types. B7H6 is expressed on various primary human tumors, including leukemia, lymphoma and gastrointestinal stromal tumors, but it is not constitutively expressed on normal tissues. | |||
| ALP8144 | O75144 -1 (D19-S258) |
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| B7-H2, also known as B7-related protein (B7RP1), ICOS Ligand, and CD275, is an approximately 60 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. B7-H2 is a ligand for the T- cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. | |||
| ALP22346 |
Recombinant CD28 Protein,Human/Cynomolgus/Rhesus Macaque,HEK293,Tag Free 重组蛋白CD28 Protein,Human/Cynomolgus/Rhesus Macaque,HEK293,Tag Free |
P10747-1/Q0PDN3/Q0PDN4(N19-P152) |
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| The CD28 protein is critical for T cell activation, enhancing proliferation, cytokine production, and survival. When linked to TCR/CD3 and CD40L, CD28 promotes the production of IL4 and IL10, thereby regulating immune responses. | |||
| ALP22179 | P27548(M112-L260) |
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| CD40L (CD154; TRAP) is a ligand to CD40/TNFRSF5, acts function by generating a costimulatory signal that up-regulates IL-4 synthesis. CD40L is specifically expressed on activated CD4+ T-lymphocytes and involves in activation of NF-κB/MAPK pathway. CD40L also involves in B cell differentiation, maturation, and apoptosis. CD40L in mouse, cleaved into 2 chains of membrane form (1-260 a.a.) and soluble form (112-260 a.a.) which serves as a ligand for integrins (ITGA5:ITGB1 and ITGAV:ITGB3). | |||
| ALP22184 | P33681-1(V35-N242) |
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| The CD80 protein plays a key role in T lymphocyte activation, promoting proliferation and cytokine production through CD28 binding. In contrast, interaction with CTLA-4 inhibits T cell activation. | |||
