辅助T细胞表面的糖蛋白，作为主要受体识别MHC II类分子，在免疫应答中协助B细胞和细胞毒性T细胞活化。
| 产品号 | 产品名称 | 蛋白编码 | 图片 |
|---|---|---|---|
| ALP22372 | I6LI22(R26-L401) |
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| CD4 Protein, an integral membrane glycoprotein , plays a pivotal role in immune responses. In T-cells, it serves as a coreceptor for MHC class II molecules, interacting with the T-cell receptor and initiating intracellular signaling pathways. In macrophages and NK cells, CD4 contributes to differentiation, cytokine expression, and cell migration independently of TCR/LCK. Additionally, CD4 is crucial in T-helper cell development, monocyte differentiation, and acts as the primary receptor for HIV-1 , down-regulated by HIV-1 Vpu, and Human Herpesvirus 7/HHV-7. | |||
| ALP22314 | P05540(K28-T394) |
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| CD4 Protein is expressed on the surface of helper T cells.It plays a key role in immune responses by binding to major histocompatibility complex class II molecules on antigen-presenting cells, facilitating T cell activation and cytokine production. CD4 Protein is also involved in immune regulation and tolerance.Understanding its functions can aid in developing therapies for autoimmune diseases and immunodeficiencies. | |||
| ALP22283 | P01730(K26-W390) |
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| CD4 Protein is an integrated membrane glycoprotein that plays various roles in immune responses and defending against internal and external attacks. The alpha-helix structure of CD4 Protein and HIV-1 Vpu can be involved in the binding and degradation of CD4 molecules. CD4 Protein participates in the differentiation/activation, cytokine expression, and cell migration in macrophages or NK cells through a TCR/LCK-independent pathway. CD4 Protein can enhance the host's immune response to viral infections and boost anti-tumor immunity. | |||
