一种主要表达于髓系细胞表面的跨膜受体，通过识别唾液酸配体调节免疫反应，在神经退行性疾病中发挥关键作用。
| 产品号 | 产品名称 | 蛋白编码 | 图片 |
|---|---|---|---|
| ALP22708 |
Recombinant Siglec-3/CD33 Protein,Cynomolgus/Rhesus Macaque,HEK293,C-His 重组蛋白Siglec-3/CD33 Protein,Cynomolgus/Rhesus Macaque,HEK293,C-His |
A0A2K5W2R5(M16-G248) |
|
| Siglec-3/CD33 , a sialic-acid-binding lectin, crucially mediates cell-cell interactions and immune cell quiescence. Preferring sialic acid on specific mucins, it forms homodimers, interacting with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation. CD33 also engages C1QA through its C-terminus, activating CD33 inhibitory motifs. | |||
| ALP22485 | P20138-1/AAH28152.1(D18-H259) |
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| Siglec-3/CD33 protein is a sialic acid-binding lectin that mediates cell-cell interactions and maintains immune cell quiescence. It prefers α-2,3- and α-2,6-linked glycans with sialic acid. | |||
| ALP22580 | Q63994-1(Q17-E240) |
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| Siglec-3/CD33 , a sialic-acid-binding lectin, crucially mediates cell-cell interactions and immune cell quiescence. Preferring sialic acid on specific mucins, it forms homodimers, interacting with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation. CD33 also engages C1QA through its C-terminus, activating CD33 inhibitory motifs. | |||
| ALP22530 | AAH28152(D18-H259) |
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| Siglec-3/CD33 , a sialic-acid-binding lectin, crucially mediates cell-cell interactions and immune cell quiescence. Preferring sialic acid on specific mucins, it forms homodimers, interacting with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation. CD33 also engages C1QA through its C-terminus, activating CD33 inhibitory motifs. | |||
