B细胞表面分化抗原，参与识别抗原、信号传导及免疫应答调控，对B细胞发育、活化和抗体产生至关重要。
| 产品号 | 产品名称 | 蛋白编码 | 图片 |
|---|---|---|---|
| ALP8099 |
Recombinant Human BAFF/TNFSF13B/CD257 Trimer Protein,Human,N-His-Flag,Expi293 重组蛋白Human BAFF/TNFSF13B/CD257 Trimer Protein,Human,N-His-Flag,Expi293 |
Q9Y275(Thr141-Leu285) |
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| BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF13C). These receptors are type III transmembrane proteins that lack a signal peptide. Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL (a proliferation-inducing ligand), BAFF R selectively binds BAFF. | |||
| ALP8207 | P25063(Ser27-Gly59) |
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| CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential for targeting CD24 in cancer therapy seems promising, as CD24 is overexpressed in many human cancers. | |||
| ALP8230 | P11049-1(Ala113-Asn240) |
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| CD37 is a tetraspanin expressed prominently on the surface of B cells. It is an attractive molecular target exploited in the immunotherapy of B cell-derived lymphomas and leukemia. Currently, several monoclonal antibodies targeting CD37 as well as chimeric antigen receptor-based immunotherapies are being developed and investigated in clinical trials. Given the unique role of CD37 in the biology of B cells, it seems that CD37 constitutes more than a docking point for monoclonal antibodies, and targeting this molecule may provide additional benefit to relapsed or refractory patients. | |||
| ALP8210 | P25063-1(Ser27-Gly59) |
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| CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential for targeting CD24 in cancer therapy seems promising, as CD24 is overexpressed in many human cancers. | |||
| ALP8225 | P28906-1(Ser32-Thr290) |
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| CD34 is a transmembrane phosphoglycoprotein, first identified on hematopoietic stem and progenitor cells. Clinically, it is associated with the selection and enrichment of hematopoietic stem cells for bone marrow transplants. Due to these historical and clinical associations, CD34 expression is almost ubiquitously related to hematopoietic cells, and it is a common misconception that CD34-positive (CD34()) cells in nonhematopoietic samples represent hematopoietic contamination. | |||
| ALP8214 | P25063(Ser27-Gly59) |
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| CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential for targeting CD24 in cancer therapy seems promising, as CD24 is overexpressed in many human cancers. | |||
| ALP8275 | P40259-1(Ala29-Asp159) |
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| CD79B (also known as B29, Ig beta and B cell antigen receptor complex-associated protein beta-chain) is a 36-40 kDa member of the Ig-Superfamily. It is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. | |||
| ALP8290 |
Recombinant Human CD84/SLAMF5 Protein,Human,C-His-Avi,Expi293 |
Q9UIB8-1(Lys22-Gly225) |
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| Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of CD5 B lymphocytes in peripheral blood, lymphoid organs and bone marrow. The main feature of the disease is accumulation of the malignant cells due to decreased apoptosis. CD84 belongs to the signaling lymphocyte activating molecule family of immunoreceptors, and has an unknown function in CLL cells. | |||
| ALP8422 | NP_940991.1(Ala22-His205) |
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| CD147, also known as extracellular matrix metalloproteinase inducer (EMMPRIN) or basigin, is expressed in a variety of cell types. It is involved in the regulation of extracellular matrix (ECM) remodeling during physiological and pathological processes including wound healing, inflammatory diseases, and cancer. CD147 is a diagnostic and therapeutic target in cancer and inflammatory diseases, either directly or indirectly, by targeting CD147 partners. | |||
| ALP24800 | Q12913-1(R997-A1337) |
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| DEP-1/CD148 protein is a tyrosine phosphatase that affects multiple targets such as CTNND1, FLT3 , PDGFRB, and EGFR , thereby affecting cellular processes such as adhesion, migration, proliferation, and differentiation. DEP-1/CD148 is critical in vascular development, regulating macrophage adhesion, platelet activation, and thrombosis, while negatively regulating cell proliferation and PDGF-stimulated migration. | |||
| ALP24806 | Q07490(N27-C55) |
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| The CD24 protein plays a critical role in cellular differentiation in various cell types, possibly triggered by binding of lectin-like ligands to the CD24 carbohydrate.This signal is transduced through second messengers released from GPI anchors. | |||
| ALP24809 | B1PLB1(E37-T291) |
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| CD34 Protein is a transmembrane phosphoglycoprotein that exists on the surface of human and various animal cells. CD34 Protein is used as a cellular marker for hematopoietic stem cell sorting and as an islet endocrine cell marker. CD34 Protein plays an important role in cell adhesion, inflammatory cell chemotaxis, cell proliferation and differentiation, and enhancement of inflammatory response. | |||
| ALP24892 | A6J740(M22-A134) |
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| The CD83 protein is involved in antigen presentation or mediating cell interactions following lymphocyte activation. The specific mechanisms by which CD83 affects these processes in the immune response have not been fully elucidated. | |||
| ALP24896 | P11609(M1-G305) |
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| CD1D protein, in partnership with B2M, functions as an antigen-presenting protein, binding self and non-self glycolipids. It presents these molecules to T-cell receptors on natural killer T-cells, playing a pivotal role in immune responses. CD1D also interacts with MHC II and CD74 , contributing to the coordination of the adaptive immune system. | |||
| ALP24897 | P11609(M1-G305) |
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| CD1D protein, in partnership with B2M, functions as an antigen-presenting protein, binding self and non-self glycolipids. It presents these molecules to T-cell receptors on natural killer T-cells, playing a pivotal role in immune responses. CD1D also interacts with MHC II and CD74 , contributing to the coordination of the adaptive immune system. | |||
| ALP24899 |
Recombinant MME/Neprilysin Protein,Rhesus Macaque,HEK293,N-His |
F7H3Y6(Y52-W750) |
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| MME is a cell-surface peptidase member of the M13 family of zinc peptidases, which also includes endothelin converting enzymes (ECE-1 and ECE-2), KELL and PEX. MME is downregulated in nearly 50% of primary and metastatic prostate cancers. | |||
| ALP22346 |
Recombinant CD28 Protein,Human/Cynomolgus/Rhesus Macaque,HEK293,Tag Free 重组蛋白CD28 Protein,Human/Cynomolgus/Rhesus Macaque,HEK293,Tag Free |
P10747-1/Q0PDN3/Q0PDN4(N19-P152) |
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| The CD28 protein is critical for T cell activation, enhancing proliferation, cytokine production, and survival. When linked to TCR/CD3 and CD40L, CD28 promotes the production of IL4 and IL10, thereby regulating immune responses. | |||
| ALP22184 | P33681-1(V35-N242) |
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| The CD80 protein plays a key role in T lymphocyte activation, promoting proliferation and cytokine production through CD28 binding. In contrast, interaction with CTLA-4 inhibits T cell activation. | |||
| ALP25046 | F6V1W6(Q26-D173) |
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| Fas receptor is a cell surface death receptor , can bind to Fas ligand to form death-inducing signaling complexes, such as Fas associated death domain proteins (FADD). Fas receptor participates in the caspase cascade and regulate the activation of JNK and p38-K downstream. It is also involved in the signaling cascade of ERK/JNK MAPKs, activating MAPK3/ERK1, MAPK8/JNK and NF-κB , which has been implicated in the pathogenesis of various malignant tumors and immune system diseases. Macaca mulatta Fas receptor contain a death domain (228-312 a.a.) that plays a key role in regulating programmed death. | |||
| ALP25048 |
Recombinant CD1D1-B2M Heterodimer Protein,Mouse,HEK293,C-His |
P11609(Q22-W297) |
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| CD1D protein, in partnership with B2M, functions as an antigen-presenting protein, binding self and non-self glycolipids. It presents these molecules to T-cell receptors on natural killer T-cells, playing a pivotal role in immune responses. CD1D also interacts with MHC II and CD74 , contributing to the coordination of the adaptive immune system. | |||
