自然杀伤细胞表面表达的簇分化抗原蛋白，参与识别和杀伤肿瘤或病毒感染细胞，调节免疫应答。
| 产品号 | 产品名称 | 蛋白编码 | 图片 |
|---|---|---|---|
| ALP8176 |
Recombinant Cynomolgus IL-2 R beta/CD122 Protein,Cynomolgus,C-His,Expi293 重组蛋白Cynomolgus IL-2 R beta/CD122 Protein,Cynomolgus,C-His,Expi293 |
Q38J85(Ala27-Asp239) |
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| IL-2 R beta is a member of the cytokine receptor superfamily. Human IL-2 R beta cDNA encodes a 551 amino acid residue precursor Type I membrane protein with a 26 residue signal peptide, a 214 residue extracellular region, a 25 residue transmembrane region and a 286 residue cytoplasmic domain. Functional IL-2 receptors can exist in two affinity states on cell surfaces, the high affinity complex consisting of heterotrimers of the alpha, beta, and gamma chains, and the intermediate affinity complex comprising heterodimers of the beta and gamma chains. | |||
| ALP8177 |
Recombinant Cynomolgus IL-2 R gamma/CD132 Protein,Cynomolgus,C-His,Expi293 重组蛋白Cynomolgus IL-2 R gamma/CD132 Protein,Cynomolgus,C-His,Expi293 |
Q38JL2(Leu23-Asn254) |
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| The gamma chain of the high affinity functional human IL-2 receptor complex belongs to the hematopoietin receptor family. IL-2 R gamma is a 369 amino acid residue protein consisting of a 22 residue signal sequence, a 232 residue extracellular domain, a 29 residue transmembrane domain and an 86 residue cytoplasmic domain. Although IL-2 R gamma by itself does not bind IL-2 with any appreciable affinity, it is required for IL-2 receptor signaling. | |||
| ALP8178 |
Recombinant Rhesus macaque CD155/PVR Protein,Rhesus macaque,C-His,Expi293 重组蛋白Rhesus macaque CD155/PVR Protein,Rhesus macaque,C-His,Expi293 |
Q0MSE6-1(Asp28-Asn343) |
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| CD155 is a cell surface adhesion molecule functioning in tumor cell migration, invasion, and metastasis, and not surprisingly, is also designated as a common tumor-associated antigen. CD155 is also recognized by NK cells to induce their cytotoxicity. CD155 is also commonly referred to as the "poliovirus receptor," or PVR. | |||
| ALP8254 | AAH05930(Phe29-Arg215) |
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| Loss of CD58 is a common mechanism for tumor immune evasion in lymphoid malignancies. CD58 loss is known to occur due to both genetic and non-genetic causes; therefore, we hypothesized that restoring CD58 expression in lymphoma cells may be an effective treatment approach. EZH2 is involved in the epigenetic silencing of CD58 in lymphoma cells as a mechanism for tumor immune escape, and EZH2 inhibitors are able to restore epigenetically suppressed CD58 expression. | |||
| ALP8295 | AAH02584(Asp23-Asp122) |
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| CD99 is a cell surface protein with unique features and only partly defined mechanisms of action. This molecule is involved in crucial biological processes, including cell adhesion, migration, death, differentiation and diapedesis, and it influences processes associated with inflammation, immune responses and cancer. CD99 is frequently overexpressed in many types of tumors, particularly pediatric tumors including Ewing sarcoma and specific subtypes of leukemia. | |||
| ALP8297 | Q13241-1(Ser34-Ile179) |
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| CD94 is an approximately 25 kDa type 2 transmembrane protein that plays an important role in regulating natural killer (NK) cell activation.CD94 plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. | |||
| ALP8296 | AAH02584(Asp23-Asp122) |
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| CD99 is a cell surface protein with unique features and only partly defined mechanisms of action. This molecule is involved in crucial biological processes, including cell adhesion, migration, death, differentiation and diapedesis, and it influences processes associated with inflammation, immune responses and cancer. CD99 is frequently overexpressed in many types of tumors, particularly pediatric tumors including Ewing sarcoma and specific subtypes of leukemia. | |||
| ALP8368 |
Recombinant Cynomolgus CRTAM Protein,Cynomolgus,C-hFc,Expi293 |
XP_005580021.1(Ser18-Gly287) |
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| Class-I Restricted T Cell-Associated Molecule (CRTAM) is a protein that is expressed after T cell activation. The interaction of CRTAM with its ligand, nectin-like 2 (Necl2), is required for the efficient production of IL-17, IL-22, and IFNγ by murine CD4 T cells, and it plays a role in optimal CD8 T and NK cell cytotoxicity. CRTAM promotes the pro-inflammatory cytokine profile; therefore, it may take part in the immunopathology of autoimmune diseases such as diabetes type 1 or colitis. | |||
| ALP8383 |
Recombinant Cynomolgus DNAM-1/CD226 Protein,Cynomolgus,C-His,Expi293 重组蛋白Cynomolgus DNAM-1/CD226 Protein,Cynomolgus,C-His,Expi293 |
A0A2K5W1Z6-1(Glu19-Phe252) |
|
| DNAX accessory molecule-1 (DNAM-1), also known as CD226, is a 65 kDa type I transmembrane glycoprotein in the immunoglobulin superfamily.DNAM-1 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155, and cross-linking DNAM-1 with antibodies causes cellular activation. Furthermore, DNAM-1 can interact with PVR and PVRL2. | |||
| ALP8384 |
Recombinant Human DNAM-1/CD226 Protein,Human,C-His-Avi,Expi293 |
Q15762(Glu19-Asn247) |
|
| DNAX accessory molecule-1 (DNAM-1), also known as CD226, is a 65 kDa type I transmembrane glycoprotein in the immunoglobulin superfamily.DNAM-1 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155, and cross-linking DNAM-1 with antibodies causes cellular activation. Furthermore, DNAM-1 can interact with PVR and PVRL2. | |||
| ALP8386 | Q15762(Glu19-Asn247) |
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| DNAX accessory molecule-1 (DNAM-1), also known as CD226, is a 65 kDa type I transmembrane glycoprotein in the immunoglobulin superfamily.DNAM-1 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155, and cross-linking DNAM-1 with antibodies causes cellular activation. Furthermore, DNAM-1 can interact with PVR and PVRL2. | |||
| ALP8369 | O95727-1(Ser18-Gly287) |
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| Class-I Restricted T Cell-Associated Molecule (CRTAM) is a protein that is expressed after T cell activation. The interaction of CRTAM with its ligand, nectin-like 2 (Necl2), is required for the efficient production of IL-17, IL-22, and IFNγ by murine CD4 T cells, and it plays a role in optimal CD8 T and NK cell cytotoxicity. CRTAM promotes the pro-inflammatory cytokine profile; therefore, it may take part in the immunopathology of autoimmune diseases such as diabetes type 1 or colitis. | |||
| ALP24809 | B1PLB1(E37-T291) |
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| CD34 Protein is a transmembrane phosphoglycoprotein that exists on the surface of human and various animal cells. CD34 Protein is used as a cellular marker for hematopoietic stem cell sorting and as an islet endocrine cell marker. CD34 Protein plays an important role in cell adhesion, inflammatory cell chemotaxis, cell proliferation and differentiation, and enhancement of inflammatory response. | |||
| ALP24844 | A0A8I6G5Q1/NP_001164034(F24-M712) |
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| Semaphorin-4D (SEMA4D) is predicted to participate in the same protein binding, signaling receptor binding, and transmembrane signaling receptor activities. Its multiple roles, including negative regulation of osteoblast differentiation and modulation of neuronal projection development, highlight its functional versatility. | |||
| ALP24845 | P14562(A22-N371) |
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| The LAMP1/CD107a protein is a lysosomal membrane glycoprotein that plays critical roles in lysosomal biogenesis, pH regulation, autophagy , and cholesterol homeostasis.It critically regulates lysosomal lumen pH by inhibiting the proton channel TMEM175, optimizing lysosomal acidification for efficient hydrolase activity. | |||
| ALP24890 | Q8VCN6(D29-G138) |
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| CD99 Protein facilitates T-cell adhesion and aids leukocytes in crossing the endothelial basement membrane during leukocyte extravasation. It functions alongside PECAM1 but acts independently. CD99 Protein forms a homodimer and interacts with PILRB. | |||
| ALP24891 | B4F7A5(D25-G127) |
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| CD99 protein is a member of the CD99 family and plays a key role in several important cellular processes such as immune response, cell adhesion and migration. It exerts a major influence on lymphocyte trafficking and is involved in the regulation of immune cell interactions. | |||
| ALP24893 | P15702(D20-G248) |
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| CD43 (mouse) is a major leukocyte surface sialic acid protein that plays a critical regulatory role in T cell function.It positively affects the activation, proliferation, differentiation, trafficking and migration of T cells, particularly by enhancing migration to lymph nodes through ERM proteins. | |||
| ALP24894 | R9PXZ7/NP_001258015.1(Q21-S243) |
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| CD43 protein is an important leukocyte surface sialic acid protein that plays a key role in T cell regulation. It has a positive impact on T cell function, including activation, proliferation, differentiation, trafficking and migration, especially by helping T cells migrate to lymph nodes through ERM proteins. | |||
| ALP25118 | A0A8C0PNZ1/XP_536556(F22-T103) |
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| CD3D protein is a component of the TCR-CD3 complex on T lymphocytes and plays a key role in adaptive immunity. It transmits signals through the CD3D , CD3E , CD3G , and CD3Z chains upon TCR engagement. | |||
