巨噬细胞表面的一组分化抗原，参与免疫识别、黏附和信号转导，对调控吞噬作用和炎症反应至关重要。
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| 产品号 | 产品名称 | 蛋白编码 | 图片 |
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| ALP6840 | NP_031958.2 (E27-K580) |
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| CD105/内皮糖蛋白是一种血管内皮糖蛋白，在血管生成调节、维持成人脉管系统的结构和完整性中发挥着至关重要的作用。它还控制血管内皮细胞的迁移，并有助于胚胎外血管生成和胚胎心脏发育。CD105/内皮糖蛋白参与响应血流的内皮细胞形状变化，促进血管生成过程中的血管重塑。此外，它还充当 TGF-β 的辅助受体，参与 TGF-β/BMP 信号级联反应并激活 SMAD 转录因子。CD105/内皮糖蛋白形成二聚体并与各种受体相互作用，包括 TGFBR1、TGFBR2、GDF2、ACVRL1、BMP10、DYNLT4 和 ARRB2。 | |||
| ALP6594 | O35235 -1 (Q137-D316) |
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| RANKL (TNFSF11)，一种 II 型跨膜蛋白，是 NF-κB 受体激活剂 (RANK) 的配体。RANKL 是 RANK 的激活剂。当与 RANK 结合后，其诱导单核细胞/巨噬细胞谱系细胞分化为破骨细胞，并进一步导致破骨细胞前体成熟。因此，RANKL 对于破骨细胞成熟、骨骼建模和骨骼重塑，以及淋巴结 (LN) 的发育至关重要。 | |||
| ALP8101 |
Human BAFF/TNFSF13B/CD257 Trimer Protein,Human,N-monomeric hFc,N-Flag,Expi293 重组蛋白Human BAFF/TNFSF13B/CD257 Trimer Protein,Human,N-monomeric hFc,N-Flag,Expi293 |
Q9Y275 -1 (T141-L285) |
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| B-cell activating factor (BAFF) also known as tumor necrosis factor ligand superfamily member 13B is a protein that in humans is encoded by the TNFSF13B gene.BAFF is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFF-R. | |||
| ALP8102 | Q9Y275 -1 (A134-L285) |
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| B-cell activating factor (BAFF) also known as tumor necrosis factor ligand superfamily member 13B is a protein that in humans is encoded by the TNFSF13B gene.BAFF is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFF-R。 | |||
| ALP6647 |
Human CD40L/CD154/TRAP Protein, Human, HEK293, N-hFc-Flag 重组蛋白Human CD40L/CD154/TRAP Protein, Human, HEK293, N-hFc-Flag |
P29965 (M113-L261) |
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| CD40L (CD154; TRAP) 是 CD40 (TNFRSF5) 的配体，在 T 细胞中产生共刺激信号而发挥上调 IL-4 合成的作用。CD40L 在活化的 CD4+ T 淋巴细胞上特异性表达，参与 NF-κB/MAPK 信号通路。CD40L 还参与 B 细胞的分化、成熟和凋亡。人 CD40L 蛋白可裂解为 2 种亚型，包括膜状肽 (1-261 a.a.) 和可溶性肽 (113-261 a.a.) (作为整合素的配体)。 | |||
| ALP8196 | Q86VB7-1(Ser42-Ser1045) |
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| The hemoglobin (Hb) scavenger receptor, CD163, is a macrophage-specific protein and the upregulated expression of this receptor is one of the major changes in the macrophage switch to alternative activated phenotypes in inflammation. Accordingly, a high CD163 expression in macrophages is a characteristic of tissues responding to inflammation. | |||
| ALP8205 | P06729(Lys25-Asp209) |
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| The CD2 family of receptors is evolutionarily conserved and widely expressed on cells within the hematopoietic compartment. In recent years several new members have been identified with important roles in the immune system. CD2 family members regulate natural killer (NK) cell lytic activity and inflammatory cytokine production when engaged by ligands on tumor cells. | |||
| ALP8199 | Q2VLH6-1(Val39-Thr1045) |
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| The hemoglobin (Hb) scavenger receptor, CD163, is a macrophage-specific protein and the upregulated expression of this receptor is one of the major changes in the macrophage switch to alternative activated phenotypes in inflammation. Accordingly, a high CD163 expression in macrophages is a characteristic of tissues responding to inflammation. | |||
| ALP8202 | P06729(Lys25-Asp209) |
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| The CD2 family of receptors is evolutionarily conserved and widely expressed on cells within the hematopoietic compartment. In recent years several new members have been identified with important roles in the immune system. CD2 family members regulate natural killer (NK) cell lytic activity and inflammatory cytokine production when engaged by ligands on tumor cells. | |||
| ALP8403 |
Recombinant Human Endoglin/CD105 Protein,Human,C-His-Avi,Expi293 |
P17813-1(Glu26-Gly586) |
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| Endoglin (CD105) is a 90 kDa type I transmembrane glycoprotein of the zona pellucida (ZP) family of proteins. Endoglin is a vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells. Required for normal extraembryonic angiogenesis and for embryonic heart development. May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis. | |||
| ALP9292 | AAH10507(Thr20-Met344) |
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| Human monocyte differentiation antigen CD14 is a pattern recognition receptor (PRR) that enhances innate immune responses. CD14 was first identified as a marker of monocytes to signal intracellular responses upon bacterial encounters. Given the absence of an intracellular tail, CD14 was doubted to have the signaling capacities. | |||
| ALP9296 | NP_033971.1(Ser16-Pro345) |
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| CD14 is a glycosylphosphatidylinositol (GPI)-anchored receptor known to serve as a co-receptor for several Toll-like Receptors (TLRs) both at the cell surface and in the endosomal compartment. CD14 can be expressed by cells of both hematopoietic and non-hematopoietic origin as a cell membrane or secreted protein. | |||
| ALP9221 | P15144(Lys69-Lys967) |
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| CD13/aminopeptidase N is a widely expressed ectoenzyme with multiple functions. As an enzyme, CD13 regulates activities of numerous cytokines by cleaving their N-terminals and is involved in Ag processing by trimming the peptides bound to MHC class II. Independent of its enzymatic activity, cell membrane CD13 functions by cross-linking-induced signal transduction, regulation of receptor recycling, enhancement of FcγR-mediated phagocytosis, and acting as a receptor for cytokines. | |||
| ALP9308 |
Recombinant Cynomolgus CD36/SR-B3 Protein,Cynomolgus,C-His,Expi293 |
Q4R6B4(Gly30-Asn439) |
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| CD36, alternatively known as platelet membrane glycoprotein IV (GPIV), GPIIIb, thrombospondin receptor, collagen receptor, fatty acid translocase (FAT), and scavenger receptor class B, member 3 (SR-B3), is an integral membrane glycoprotein that has multiple physiological functions.CD36 is a multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. | |||
| ALP9222 | P97449(Lys69-Ser966) |
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| CD13/aminopeptidase N is a widely expressed ectoenzyme with multiple functions. As an enzyme, CD13 regulates activities of numerous cytokines by cleaving their N-terminals and is involved in Ag processing by trimming the peptides bound to MHC class II. Independent of its enzymatic activity, cell membrane CD13 functions by cross-linking-induced signal transduction, regulation of receptor recycling, enhancement of FcγR-mediated phagocytosis, and acting as a receptor for cytokines. | |||
| ALP9316 |
Recombinant Cynomolgus CD43 Protein,Cynomolgus,C-His,Expi293 |
XP_005591704.2(Asp20-Leu253) |
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| CD43 (leukosialin) is a large sialoglycoprotein abundantly expressed on the surface of most cells from the hematopoietic lineage. CD43 is directly involved in the contact between cells participating in a series of events such as signaling, adherence and host parasite interactions. The induction of acute myocarditis involves the engagement of CD43 cytoplasmic tripeptide sequence KRR to ezrin-radixin-moiesin cytoskeletal proteins. | |||
| ALP9318 | P16150(Ser20-Arg253) |
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| CD43 (leukosialin) is a large sialoglycoprotein abundantly expressed on the surface of most cells from the hematopoietic lineage. CD43 is directly involved in the contact between cells participating in a series of events such as signaling, adherence and host parasite interactions. The induction of acute myocarditis involves the engagement of CD43 cytoplasmic tripeptide sequence KRR to ezrin-radixin-moiesin cytoskeletal proteins. | |||
| ALP8982 | Q9NNX6-1(Gln59-Ala404) |
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| C-type lectin CD209/DC-SIGN and CD209L/L-SIGN proteins are distinct cell adhesion and pathogen recognition receptors that mediate cellular interactions and recognize a wide range of pathogens, including viruses such as SARS, SARS-CoV-2, bacteria, fungi and parasites. Pathogens exploit CD209 family proteins to promote infection and evade the immune recognition system. | |||
| ALP9079 | NP_061113.1(Ala21-Arg200) |
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| TREM1 (Triggering Receptor Expressed on Myeloid Cells 1) is a pro-inflammatory receptor expressed by phagocytes, which can also be released as a soluble molecule (sTREM1). The roles of TREM1 and sTREM1 in liver infection and inflammation are not clear. | |||
| ALP9485 | Q99062-1(Glu25-His627) |
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| The Granulocyte Colony-Stimulating Factor (G-CSF) receptor, a member of the hematopoietin cytokine receptor superfamily, functions as a homodimer and requires the recruitment of cytosolic protein tyrosine kinases (PTKs) to transduce its signal. | |||
