介导免疫球蛋白G抗体Fc段与效应细胞结合的受体，参与抗体依赖性细胞毒作用、吞噬作用和炎症反应调节。
| 产品号 | 产品名称 | 蛋白编码 | 图片 |
|---|---|---|---|
| ALP8307 |
Recombinant Human Fc gamma RIIB/CD32b Protein,Human,C-His-Avi,Expi293 重组蛋白Human Fc gamma RIIB/CD32b Protein,Human,C-His-Avi,Expi293 |
P31994-1(Ala46-Pro217) |
|
| The Fc gamma Rs have been divided into three classes based on close relationships in their extracellular domains; these groups are designated Fc gamma RI (also known as CD64), Fc gamma RII (CD32), and Fc gamma RIII (CD16). Each group may be encoded by multiple genes and exist in different isoforms depending on species and cell type. | |||
| ALP8309 |
Recombinant Mouse Fc gamma RIIB/CD32b Protein,Mouse,C-His,Expi293 |
NP_001070657.1(Thr40-Arg217) |
|
| The Fc gamma Rs have been divided into three classes based on close relationships in their extracellular domains; these groups are designated Fc gamma RI (also known as CD64), Fc gamma RII (CD32), and Fc gamma RIII (CD16). Each group may be encoded by multiple genes and exist in different isoforms depending on species and cell type. The CD64 proteins are high affinity receptors (~10e-8-10e-9 M) capable of binding monomeric IgG, whereas the CD16 and CD32 proteins bind IgG with lower affinities (~10e-6-10e-7 M) only recognizing IgG aggregates surrounding multivalent antigens. | |||
| ALP8301 |
Recombinant Cynomolgus Fc gamma RIIA/CD32a Protein,Cynomolgus,C-His,Expi293 重组蛋白Cynomolgus Fc gamma RIIA/CD32a Protein,Cynomolgus,C-His,Expi293 |
Q8SPW4-1(Gln28-Pro208) |
|
| The Fc gamma Rs have been divided into three classes based on close relationships in their extracellular domains; these groups are designated Fc gamma RI (also known as CD64), Fc gamma RII (CD32), and Fc gamma RIII (CD16). Each group may be encoded by multiple genes and exist in different isoforms depending on species and cell type. The CD64 proteins are high affinity receptors (~10e-8-10e-9 M) capable of binding monomeric IgG, whereas the CD16 and CD32 proteins bind IgG with lower affinities (~10e-6-10e-7 M) only recognizing IgG aggregates surrounding multivalent antigens. | |||
| ALP8304 |
Recombinant Human Fc gamma RIIA/CD32a (H167) Protein,Human,C-His-Avi,Expi293 重组蛋白Human Fc gamma RIIA/CD32a (H167) Protein,Human,C-His-Avi,Expi293 |
P12318-1(Ala36-Ile218(H167)) |
|
| The Fc gamma Rs have been divided into three classes based on close relationships in their extracellular domains; these groups are designated Fc gamma RI (also known as CD64), Fc gamma RII (CD32), and Fc gamma RIII (CD16). Each group may be encoded by multiple genes and exist in different isoforms depending on species and cell type. | |||
| ALP8302 |
Recombinant Human Fc gamma RIIIA/CD16a (F176) Protein,Human,C-His-Avi,Expi293 重组蛋白Human Fc gamma RIIIA/CD16a (F176) Protein,Human,C-His-Avi,Expi293 |
P08637-1(Gly17-Gln208(F176)) |
|
| Human Fc gamma RIIIA/CD16a Protein is a receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. | |||
| ALP8306 |
Recombinant Cynomolgus Fc gamma RIIB Protein,Cynomolgus,C-His,Expi293 重组蛋白Cynomolgus Fc gamma RIIB Protein,Cynomolgus,C-His,Expi293 |
Q8SPW3(Ala46-Pro224) |
|
| The Fc gamma Rs have been divided into three classes based on close relationships in their extracellular domains; these groups are designated Fc gamma RI (also known as CD64), Fc gamma RII (CD32), and Fc gamma RIII (CD16). Each group may be encoded by multiple genes and exist in different isoforms depending on species and cell type. The CD64 proteins are high affinity receptors (~10e-8-10e-9 M) capable of binding monomeric IgG, whereas the CD16 and CD32 proteins bind IgG with lower affinities (~10e-6-10e-7 M) only recognizing IgG aggregates surrounding multivalent antigens. | |||
| ALP8432 |
Recombinant Human Fc gamma RIIIB/CD16b (NA1) Protein,Human,C-His,Expi293 重组蛋白Human Fc gamma RIIIB/CD16b (NA1) Protein,Human,C-His,Expi293 |
AAA35881.1(Gly17-Ser200) |
|
| Human Fc gamma RIIIB/CD16b Protein is a receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils. | |||
| ALP8435 |
Recombinant Human Fc gamma RIIA/CD32a (R167) Protein,Human,C-His-Avi,Expi293 重组蛋白Human Fc gamma RIIA/CD32a (R167) Protein,Human,C-His-Avi,Expi293 |
P12318-1(Ala36-Ile218) |
|
| The Fc gamma Rs have been divided into three classes based on close relationships in their extracellular domains; these groups are designated Fc gamma RI (also known as CD64), Fc gamma RII (CD32), and Fc gamma RIII (CD16). Each group may be encoded by multiple genes and exist in different isoforms depending on species and cell type. The CD64 proteins are high affinity receptors (~10e-8-10e-9 M) capable of binding monomeric IgG, whereas the CD16 and CD32 proteins bind IgG with lower affinities (~10e-6-10e-7 M) only recognizing IgG aggregates surrounding multivalent antigens. | |||
| ALP8436 |
Recombinant Biotinylated Human Fc gamma RIIA/CD32a (R167) Protein,Human,C-His-Avi,Expi293 重组蛋白Biotinylated Human Fc gamma RIIA/CD32a (R167) Protein,Human,C-His-Avi,Expi293 |
P12318-1(Ala36-Ile218) |
|
| The Fc gamma Rs have been divided into three classes based on close relationships in their extracellular domains; these groups are designated Fc gamma RI (also known as CD64), Fc gamma RII (CD32), and Fc gamma RIII (CD16). Each group may be encoded by multiple genes and exist in different isoforms depending on species and cell type. The CD64 proteins are high affinity receptors (~10e-8-10e-9 M) capable of binding monomeric IgG, whereas the CD16 and CD32 proteins bind IgG with lower affinities (~10e-6-10e-7 M) only recognizing IgG aggregates surrounding multivalent antigens. | |||
| ALP8437 |
Recombinant Human Fc gamma RIIIB/CD16b (NA2) Protein,Human,C-His-Avi,Expi293 重组蛋白Human Fc gamma RIIIB/CD16b (NA2) Protein,Human,C-His-Avi,Expi293 |
O75015-1(Gly17-Ser200) |
|
| Human Fc gamma RIIIB/CD16b Protein is a receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils. | |||
| ALP8439 |
Recombinant Human Fc gamma RIIIA/CD16a (V176) Protein,Human,C-His-Avi,Expi293 重组蛋白Human Fc gamma RIIIA/CD16a (V176) Protein,Human,C-His-Avi,Expi293 |
AAH17865(Gly17-Gln208) |
|
| Human Fc gamma RIIIA/CD16a Protein is a receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. | |||
| ALP8441 |
Recombinant Mouse Fc gamma RIV/CD16-2 Protein,Mouse,C-His,Expi293 |
A0A0B4J1G0-1(Gly21-Gln203) |
|
| FcgammaRIV is a relatively new IgG Fc receptor (FcgammaR) that is reported to contribute to the pathogenesis of autoimmune diseases.FcgammaRIII and FcgammaRIV are each essential to trigger an FcRgamma-linker for activation of T-cell-dependent signal that drives C5a production in the Arthus reaction. A combined requirement for FcgammaRIII and FcgammaRIV in autoimmune injury, and identify the linker for activation of T cells adaptor as an integral component of linked FcgammaR and C5a anaphylatoxin receptor activation to generate inflammation. | |||
| ALP8472 |
Recombinant Cynomolgus Fc gamma RIII/CD16 Protein,Cynomolgus,C-His,Expi293 重组蛋白Cynomolgus Fc gamma RIII/CD16 Protein,Cynomolgus,C-His,Expi293 |
Q8SPW2-1(Gly17-Gln208) |
|
| Immunoglobulin G (IgG) Fc receptors play a critical role in linking IgG antibody-mediated immune responses with cellular effector functions. A high resolution map of the binding site on human IgG1 for human Fc gamma RI, Fc gamma RIIA, Fc gamma RIIB, Fc gamma RIIIA, and FcRn receptors has been determined.A common set of IgG1 residues is involved in binding to all Fc gamma R; Fc gamma RII and Fc gamma RIII also utilize residues outside this common set. | |||
| ALP8481 |
Recombinant Mouse Fc gamma RIII/CD16 Protein,Mouse,C-His,Expi293 |
Q5D5I8(Leu32-Thr215) |
|
| Immunoglobulin G (IgG) Fc receptors play a critical role in linking IgG antibody-mediated immune responses with cellular effector functions. A high resolution map of the binding site on human IgG1 for human Fc gamma RI, Fc gamma RIIA, Fc gamma RIIB, Fc gamma RIIIA, and FcRn receptors has been determined.A common set of IgG1 residues is involved in binding to all Fc gamma R; Fc gamma RII and Fc gamma RIII also utilize residues outside this common set. | |||
| ALP8490 |
Recombinant Biotinylated Human Fc gamma RI/CD64 Protein,Human,C-His-Avi,Expi293 重组蛋白Biotinylated Human Fc gamma RI/CD64 Protein,Human,C-His-Avi,Expi293 |
P12314-1(Gln16-Pro288) |
|
| The Fc gamma Rs have been divided into three classes based on close relationships in their extracellular domains; these groups are designated Fc gamma RI (also known as CD64), Fc gamma RII (CD32), and Fc gamma RIII (CD16). Each group may be encoded by multiple genes and exist in different isoforms depending on species and cell type. | |||
| ALP8489 |
Recombinant Human Fc gamma RI/CD64 Protein,Human,C-His-Avi,Expi293 |
P12314-1(Gln16-Pro288) |
|
| The Fc gamma Rs have been divided into three classes based on close relationships in their extracellular domains; these groups are designated Fc gamma RI (also known as CD64), Fc gamma RII (CD32), and Fc gamma RIII (CD16). Each group may be encoded by multiple genes and exist in different isoforms depending on species and cell type. | |||
| ALP9451 |
Recombinant Mouse Fc gamma RI/CD64 Protein,Mouse,C-His,Expi293 |
P26151-1(Glu25-Pro297) |
|
| The Fc gamma Rs have been divided into three classes based on close relationships in their extracellular domains; these groups are designated Fc gamma RI (also known as CD64), Fc gamma RII (CD32), and Fc gamma RIII (CD16). Each group may be encoded by multiple genes and exist in different isoforms depending on species and cell type. The CD64 proteins are high affinity receptors (~10e-8-10e-9 M) capable of binding monomeric IgG, whereas the CD16 and CD32 proteins bind IgG with lower affinities (~10e-6-10e-7 M) only recognizing IgG aggregates surrounding multivalent antigens. | |||
| ALP6337 | P08508-1(Ala31-Thr215) |
|
|
| Fc receptors bind the most common class of antibody, IgG, are called Fc gamma receptors (FcγR). FcγR is divided into three classes, Fc γ RI (CD64), Fc γ RII (CD32), and Fc γ RIII (CD16). CD16 protein is a multifunctional, low/intermediate affinity receptor, which belongs to the immunoglobulin superfamily. It is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages. Mouse CD16 is encoded by a single gene, while, human CD16 is expressed as two distinct forms (CD16a/FcγRIIIa and CD16b/FcγRIIIb) encoded by two different highly homologous genes in a cell type-specific manner. CD16 is involved in phagocytosis, secretion of enzymes, inflammatory mediators, antibody-dependent cellular cytotoxicity (ADCC), and clearance of immune complexes. | |||
| ALP22140 |
Recombinant Biotinylated Fc gamma RIIA/CD32a Protein,Human,HEK293,C-His-Avi 重组蛋白Biotinylated Fc gamma RIIA/CD32a Protein,Human,HEK293,C-His-Avi |
P12318-1(A36-I218) |
|
| Fc gamma The RIIA/CD32a protein plays a key role as a low-affinity receptor that specifically binds to the Fc region of immunoglobulin gamma. It interacts with IgG to initiate cellular responses against pathogens, which is critical for immune regulation. | |||
| ALP22143 |
Recombinant Biotinylated CD64 Protein,Human,272a.a,HEK293,C-His-Avi |
P12314-1(Q16-T287) |
|
| CD64 protein, a high affinity receptor, mediates IgG effector functions, triggering antibody-dependent cellular cytotoxicity (ADCC). It interacts with IGHG1 and forms a signaling complex with FCERG1, contributing to immune responses. CD64 also interacts with FLNA, EPB41L2, LAT, PPL, HCK , and LYN to prevent degradation of FCGR1A and regulate immune function. | |||
