一类与抗体Fc段结合的膜蛋白，参与免疫调节和信号转导，在B细胞发育和功能中发挥关键作用。
| 产品号 | 产品名称 | 蛋白编码 | 图片 |
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| ALP22229 | Q96LA5-1/NP_110391.2(L20-D395) |
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| The FCRL2 protein regulates normal and neoplastic B cell development and has been shown to be involved in complex processes that control B cell maturation. Its tyrosine-phosphorylated isoform 2 interacts with PTPN6, suggesting the existence of a signaling pathway and emphasizing the role of this protein in cellular regulation. | |||
| ALP8433 | Q96RD9-1(Gln16-Gly851) |
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| FcRH5 is a cell surface marker enriched on malignant plasma cells when compared to other hematologic malignancies and normal tissues. DFRF4539A is an anti-FcRH5 antibody-drug conjugated to monomethyl auristatin E (MMAE), a potent anti-mitotic agent. | |||
| ALP9430 | Q6DN72-1(Leu20-Trp307) |
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| Fc receptor-like 6 (FCRL6), the most recently characterized member of the FCRL family, is a cell surface glycoprotein with tyrosine-based regulatory potential. An extensive survey of human hematopoietic tissues disclosed that FCRL6 expression by NK- and T-cell subpopulations increases as a function of differentiation and is remarkably restricted to mature lymphocytes with cytotoxic capability. | |||
| ALP9431 | Q6DN72-1(Leu20-Trp307) |
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| A surprising number of Fc receptor (FcR) relatives have been recognized recently with the potential capacity to modulate innate and adaptive immune responses. The six human FcR homologs (FcRH1-6), which belong to a phylogenetically conserved gene family, have variable numbers of extracellular immunoglobulin domains of five different subtypes. All but one of these new receptors, FcRH6, are expressed on B cells at different stages in differentiation. | |||
| ALP9432 | Q68SN8-1(Gln27-Ala496) |
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| FcRH5 is a cell surface marker enriched on malignant plasma cells when compared to other hematologic malignancies and normal tissues. DFRF4539A is an anti-FcRH5 antibody-drug conjugated to monomethyl auristatin E (MMAE), a potent anti-mitotic agent. | |||
| ALP22224 | A0A0R4J0W8/BAC30017.1(A17-S219) |
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| Fc receptor-like protein 1 (Fcrl1) is a cell-surface membrane protein that belongs to FCRL family. Fcrl1 is a BCR co-receptor and enhance signaling through the B cell receptor. Fcrl1 promotes B cell proliferation and calcium mobilization. Fcrl1 is a biomarker and an important target in B cell lymphoproliferative disorders. | |||
| ALP22222 | Q96LA6-1(A17-N303) |
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| The FCRL1 protein may act as an activation coreceptor in B cells, suggesting involvement in B cell activation and differentiation processes. The dual role of FCRL1 makes it a key player in regulating B cell responses and enhancing signaling pathways associated with B cell activation. | |||
| ALP22235 | Q96LA5-1(L20-D395) |
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| The FCRL2 protein regulates normal and neoplastic B cell development and has been shown to be involved in complex processes that control B cell maturation. Its tyrosine-phosphorylated isoform 2 interacts with PTPN6, suggesting the existence of a signaling pathway and emphasizing the role of this protein in cellular regulation. | |||
