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表达系统:	E. coli (1)
标签:	Tag Free (1)

产品号	产品名称	蛋白编码
ALP6846	Human UbcH5b/UBE2D2 Protein, Human, E.coli, Tag Free 重组蛋白Human UbcH5b/UBE2D2 Protein, Human, E.coli, Tag Free	P62837 -1 (M1-M147)
ALP6846	UbcH5b/UBE2D2 蛋白是一种重要的细胞介质，它接受 E1 复合物中的泛素并催化靶蛋白上的多功能“Lys-48”连接的多泛素化。除了其催化作用外，它还浓缩并选择性地降解短寿命蛋白质，并有助于 E6/E6-AP 诱导的 p53/TP53 泛素化。
ALP8955	Recombinant Human RNF43 Protein,Human,C-hFc,Expi293 重组蛋白Human RNF43 Protein,Human,C-hFc,Expi293	Q68DV7(Gly24-Tyr197)
ALP8955	RNF43 (E3 ubiquitin-protein ligase RNF43 or RING-type E3 ubiquitin transferase RNF43) functions as a tumor suppressor, by exerting a predominant negative feedback mechanism in the Wnt/β-catenin signaling pathway. RNF43 inhibits Wnt/beta-catenin signaling by ubiquitinating Frizzled receptor and targeting it to the lysosomal pathway for degradation.
ALP9743	Recombinant Mouse RNF43 Protein,Mouse,C-hFc,Expi293 重组蛋白Mouse RNF43 Protein,Mouse,C-hFc,Expi293	Q5NCP0(Gly24-Tyr197)
ALP9743	RNF43 (E3 ubiquitin-protein ligase RNF43 or RING-type E3 ubiquitin transferase RNF43) functions as a tumor suppressor, by exerting a predominant negative feedback mechanism in the Wnt/β-catenin signaling pathway. RNF43 inhibits Wnt/beta-catenin signaling by ubiquitinating Frizzled receptor and targeting it to the lysosomal pathway for degradation.
ALP22750	Recombinant XIAP Protein,Human,E. coli,N-His 重组蛋白XIAP Protein,Human,E. coli,N-His	P98170(N252-T356)
ALP22750	XIAP protein is a multifunctional regulator that controls apoptosis , inflammation, immunity, copper homeostasis, and various signaling pathways. As a caspase inhibitor , it blocks CASP3 and CASP7 substrate access, keeping CASP9 inactive.
ALP22751	Recombinant ATG3 Protein,Human,E. coli,Tag Free 重组蛋白ATG3 Protein,Human,E. coli,Tag Free	Q9NT62(M1-M314)
ALP22751	ATG3, the E2 ubiquitin-conjugating enzyme for the LC3 lipidation process, is essential for autophagy.
ALP22753	Recombinant UBE2B Protein,Human,HEK293,C-His 重组蛋白UBE2B Protein,Human,HEK293,C-His	P63146(M1-S152)
ALP22753	The UBE2B protein is a key ubiquitination factor that acts as an E2 ubiquitin-conjugating enzyme, accepting ubiquitin from the E1 complex and catalyzing covalent attachment to proteins. UBE2B works in conjunction with the BRE1 (RNF20 and/or RNF40) E3 enzyme and plays a key role in transcriptional regulation by catalyzing the monoubiquitination of histone H2B at "Lys-120" (H2BK120ub1).
ALP22754	Recombinant XIAP Protein,Human,E. coli,C-Avi 重组蛋白XIAP Protein,Human,E. coli,C-Avi	P98170(L121-T356)
ALP22754	XIAP protein is a multifunctional regulator that controls apoptosis , inflammation, immunity, copper homeostasis, and various signaling pathways. As a caspase inhibitor , it blocks CASP3 and CASP7 substrate access, keeping CASP9 inactive.
ALP22756	Recombinant UBE2D3 Protein,Human,E. coli,Tag Free 重组蛋白UBE2D3 Protein,Human,E. coli,Tag Free	AAH66917(M1-M147)
ALP22756	UBE2D3 is able to accept ubiquitin from specific E2 ubiquitin-conjugating enzymes and transfer it to substrates, often promoting its degradation by the proteasome.
ALP22760	Recombinant MDM2 Protein,Human,E. coli,Tag Free 重组蛋白MDM2 Protein,Human,E. coli,Tag Free	Q00987(S17-N111)
ALP22760	MDM2 protein is a key E3 ubiquitin protein ligase that coordinates cellular processes by ubiquitinating and degrading p53/TP53 and inhibiting its tumor suppressor function. In addition to p53/TP53 regulation, MDM2 inhibits p53/TP53- and p73/TP73-mediated responses, self-ubiquitinates, and targets ARRB1 for degradation.
ALP22763	Recombinant MDM2 Protein,Human,E. coli,N-His 重组蛋白MDM2 Protein,Human,E. coli,N-His	Q00987(S17-N111)
ALP22763	MDM2 protein is a key E3 ubiquitin protein ligase that coordinates cellular processes by ubiquitinating and degrading p53/TP53 and inhibiting its tumor suppressor function. In addition to p53/TP53 regulation, MDM2 inhibits p53/TP53- and p73/TP73-mediated responses, self-ubiquitinates, and targets ARRB1 for degradation.
ALP22764	Recombinant UBE2G1 Protein,Human,E. coli,Tag Free 重组蛋白UBE2G1 Protein,Human,E. coli,Tag Free	P62253(M1-E170)
ALP22764	The UBE2G1 protein is an important participant in the ubiquitin-proteasome system, acting as an E2 ubiquitin-conjugating enzyme to promote the attachment of ubiquitin to different protein substrates. In vitro, UBE2G1 exhibits catalytic ability in “Lys-48” and “Lys-63” linked polyubiquitination reactions.
ALP22765	Recombinant UBE2D1 Protein,Human,E. coli,N-GST 重组蛋白UBE2D1 Protein,Human,E. coli,N-GST	P51668(M1-M147)
ALP22765	The UBE2D1 protein is critical in cellular processes. It accepts ubiquitin from the E1 complex and preferentially catalyzes "Lys-48"-linked polyubiquitination in vitro, demonstrating multifunctionality. It mediates the selective degradation of short-lived and aberrant proteins and is involved in E6/E6-AP-induced ubiquitination of p53/TP53.
ALP22766	Recombinant UBE2K Protein,Human,E. coli,N-GST 重组蛋白UBE2K Protein,Human,E. coli,N-GST	P61086-1(M1-N200)
ALP22766	UBE2K protein is an important component of the ubiquitin-proteasome system and functions as an E2 ubiquitin-conjugating enzyme, which is critical for attaching ubiquitin to different substrates. In vitro, UBE2K catalyzes "Lys-48" linked polyubiquitin chains, specifically in the presence or absence of the BRCA1-BARD1 E3 ligase complex.
ALP22767	Recombinant UBE2T Protein,Human,E. coli,N-His 重组蛋白UBE2T Protein,Human,E. coli,N-His	Q9NPD8(M1-V197)
ALP22767	UBE2T protein is an important ubiquitination component. As an E2 ubiquitin-conjugating enzyme, it accepts ubiquitin in the E1 complex and catalyzes its covalent attachment to proteins. This multifaceted enzyme catalyzes monoubiquitination, which is critical during MMC-induced DNA repair.
ALP22768	Recombinant RNF43 Protein,Human,HEK293,C-His 重组蛋白RNF43 Protein,Human,HEK293,C-His	Q68DV7-1/NP_060233.3(G24-Y197)
ALP22768	RNF43 protein is encoded by the RNF43 gene and is a RING-type E3 ubiquitin ligase . It negatively regulates Wnt signaling by increasing ubiquitination of Frizzled receptors, resulting in reduced surface levels of these receptors.
ALP22769	Recombinant RNF114 Protein,Human,E. coli,Tag Free 重组蛋白RNF114 Protein,Human,E. coli,Tag Free	Q9Y508(A2-Q228)
ALP22769	The RNF114 protein is an E3 ubiquitin protein ligase that critically regulates a variety of cellular processes by ubiquitinating various substrates. RNF114 is involved in cell cycle progression, apoptosis , osteoclastogenesis and immunity, serving as a negative regulator of NF-kappa-B-dependent transcription, affecting immune responses by ubiquitinating TNFAIP3 and potentially TRAF6.
ALP22771	Recombinant ITCH/AIP4 Protein,Human,E. coli,Tag Free 重组蛋白ITCH/AIP4 Protein,Human,E. coli,Tag Free	Q96J02-2/NP_113671.3(R485-E862)
ALP22771	ITCH/AIP4 protein is an E3 ubiquitin protein ligase that catalyzes the conjugation of “Lys-29”, “Lys-48” and “Lys-63” linked ubiquitin, affecting inflammatory signaling pathways. It forms a ubiquitin editing complex that promotes RIPK1 degradation and terminates TNF- or LPS-mediated NFKB1 activation.
ALP22772	Recombinant UBE2A Protein,Human,E. coli,N-GST-His 重组蛋白UBE2A Protein,Human,E. coli,N-GST-His	P49459-1(M1-C152)
ALP22772	UBE2A cooperates with the E3 enzyme BRE1 to promote the attachment of ubiquitin to proteins, specifically histone H2B at "Lys-120", forming H2BK120ub1. This modification serves as a tag for transcriptional activation, RNA polymerase II elongation, telomeric silencing, and is critical for the formation of H3K4me and H3K79me.
ALP22773	Recombinant UBE2I Protein,Human,E. coli,N-GST 重组蛋白UBE2I Protein,Human,E. coli,N-GST	P63279(M1-S158)
ALP22773	The UBE2I protein is a key player in protein sumoylation, accepting the ubiquitin-like proteins SUMO1, SUMO2, SUMO3, SUMO4 and SUMO1P1/SUMO5 from the UBLE1A-UBLE1B E1 complex. UBE2I cooperates with E3 ligases such as RANBP2, CBX4, and ZNF451 to catalyze the covalent attachment of these SUMO proteins to target proteins, including key substrates FOXL2 and KAT5.
ALP22775	Recombinant UBE2H Protein,Human,E. coli,N-GST 重组蛋白UBE2H Protein,Human,E. coli,N-GST	P62256(M1-L183)
ALP22775	UBE2H Protein, a crucial participant in cellular ubiquitination, transfers ubiquitin from the E1 complex to various proteins, including MAEA of the CTLH E3 ubiquitin-protein ligase complex. Versatile in vitro, UBE2H catalyzes both 'Lys-11'- and 'Lys-48'-linked polyubiquitination, showcasing its involvement in diverse ubiquitin-related processes. Notably, it demonstrates the capability to ubiquitinate histone H2A in vitro.

Ubiquitin Enzymes