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Deubiquitinase

去泛素化酶通过切割泛素链,逆转蛋白质泛素化修饰,调控蛋白质稳定性、信号转导及细胞周期等关键过程。

产品号 产品名称 蛋白编码 图片
ALP22748

Recombinant UCHL1 Protein,Mouse,E. coli,N-His

重组蛋白UCHL1 Protein,Mouse,E. coli,N-His

Q9R0P9(Q2-A223) 重组蛋白UCHL1 Protein,Mouse,E. coli,N-His
UCHL1 Protein, a ubiquitin carboxyl-terminal hydrolase, plays a crucial role in protein degradation and regulation of cellular processes.It is involved in maintaining neuronal integrity and has been linked to neurodegenerative diseases. UCHL1 Protein's potential as a biomarker and therapeutic target in neurodegenerative disorders makes it a subject of intense research in the field of neuroscience.
ALP22752

Recombinant USP14 Protein,Human,E. coli,N-His

重组蛋白USP14 Protein,Human,E. coli,N-His

P54578-1(D91-Q494) 重组蛋白USP14 Protein,Human,E. coli,N-His
USP14 is a proteasome-associated deubiquitinase that regulates ubiquitin dynamics by releasing ubiquitin from proteins marked for degradation. As a reversible proteasome subunit, USP14 ensures ubiquitin replenishment.
ALP22755

Recombinant UCHL1 Protein,Rat,E. coli,N-His

重组蛋白UCHL1 Protein,Rat,E. coli,N-His

Q00981(Q2-A223) 重组蛋白UCHL1 Protein,Rat,E. coli,N-His
The UCHL1 protein is a ubiquitin proteolytic enzyme essential for processing ubiquitin precursors and hydrolyzing ubiquitinated proteins.
ALP22757

Recombinant OTUB1 Protein,Human,E. coli,N-His

重组蛋白OTUB1 Protein,Human,E. coli,N-His

Q96FW1-1(M1-K271) 重组蛋白OTUB1 Protein,Human,E. coli,N-His
OTUB1 protein directly interacts with RNF128, forming a ternary complex with USP8 through OTUB1's binding to the C-terminal UCH catalytic domain of USP8 .
ALP22758

Recombinant UCHL1 Protein,Human,E. coli,C-His

重组蛋白UCHL1 Protein,Human,E. coli,C-His

P09936(M1-A223) 重组蛋白UCHL1 Protein,Human,E. coli,C-His
The UCHL1 protein is a multifunctional deubiquitinase that regulates a variety of cellular processes. It maintains synaptic and cardiac function, modulates inflammatory responses, and influences osteoclastogenesis.
ALP22770

Recombinant USP25 Protein,Human,E. coli,Tag Free

重组蛋白USP25 Protein,Human,E. coli,Tag Free

Q9UHP3(T2-R1055) 重组蛋白USP25 Protein,Human,E. coli,Tag Free
The USP25 protein acts as a deubiquitinating enzyme and plays a key role in the hydrolysis of the ubiquitin moiety conjugated to the substrate. This function enables processing of newly synthesized ubiquitin, recycling of ubiquitin molecules, and editing of polyubiquitin chains, thus preventing proteasomal degradation of substrates.
ALP22791

Recombinant USP7 Protein,Human,E. coli,N-His

重组蛋白USP7 Protein,Human,E. coli,N-His

Q93009-1(K208-E560) 重组蛋白USP7 Protein,Human,E. coli,N-His
The USP7 protein is a hydrolase that deubiquitinates multiple targets, including FOXO4, DEPTOR, KAT5, p53/TP53, MDM2 , ERCC6, DNMT1 , UHRF1 , PTEN , KMT2E/MLL5, and DAXX. It cooperates with DAXX to enhance the E3 ligase activity of MDM2 and promote ubiquitination and degradation of p53/TP53.
ALP22795

Recombinant OTUB2 Protein,Human,E. coli,N-His

重组蛋白OTUB2 Protein,Human,E. coli,N-His

Q96DC9-1(M1-H234) 重组蛋白OTUB2 Protein,Human,E. coli,N-His
OTUB2 is a hydrolase that efficiently removes conjugated ubiquitin from proteins in vitro, implying a crucial role in preventing protein degradation and regulating turnover. Its deubiquitinating activity targets “Lys-11”, “Lys-48” and “Lys-63” linked polyubiquitin chains, with preference for the latter.
ALP22807

Recombinant UCHL3 Protein,Human,E. coli,C-His

重组蛋白UCHL3 Protein,Human,E. coli,C-His

P15374(M1-A230) 重组蛋白UCHL3 Protein,Human,E. coli,C-His
UCHL3 Protein, a ubiquitin carboxyl-terminal hydrolase, is responsible for protein degradation and regulation of cellular processes.
ALP22811

Recombinant USP46 Protein,Human,E. coli,Tag Free

重组蛋白USP46 Protein,Human,E. coli,Tag Free

P62068(M1-E366) 重组蛋白USP46 Protein,Human,E. coli,Tag Free
USP46 protein, as a deubiquitinating enzyme, may participate in behavioral regulation by regulating the effects of GABA. Suggested to mediate deubiquitination of GAD1/GAD67, affecting processes related to GABAergic neurotransmission.
ALP22819

Recombinant UCHL3 Protein,Rat,E. coli,N-His

重组蛋白UCHL3 Protein,Rat,E. coli,N-His

Q91Y78(E2-A230) 重组蛋白UCHL3 Protein,Rat,E. coli,N-His
The UCHL3 protein is a deubiquitinating enzyme (DUB) that complexly controls cellular ubiquitin levels by processing ubiquitin precursors and ubiquitinated proteins.
ALP22820

Recombinant USP21 Protein,Human,E. coli,Tag Free

重组蛋白USP21 Protein,Human,E. coli,Tag Free

Q9UK80(P2-L565) 重组蛋白USP21 Protein,Human,E. coli,Tag Free
USP21 protein is a multifunctional deubiquitinase that plays a key role in the regulation of epigenetic transcriptional repression by deubiquitinating histone H2A. As a coactivator, it relieves the inhibition of dimethylation and trimethylation of histone H3 at "Lys-4", thereby regulating transcription initiation.
ALP22824

Recombinant USP1 Protein,Human,E. coli,N-His

重组蛋白USP1 Protein,Human,E. coli,N-His

O94782(M1-L785) 重组蛋白USP1 Protein,Human,E. coli,N-His
USP1 Protein, Human (His) is the recombinant human-derived USP1 , expressed by E. coli , with N-6*His labeled tag. ,
ALP22825

Recombinant USP2 Catalytic Domain Protein,Human,E. coli,N-His

重组蛋白USP2 Catalytic Domain Protein,Human,E. coli,N-His

O75604-1(N259-M605) 重组蛋白USP2 Catalytic Domain Protein,Human,E. coli,N-His
USP2 catalytic domain proteins act as hydrolases and target polyubiquitinated proteins such as MDM2 , MDM4, and CCND1. Both isoform 1 and isoform 4 exhibit ubiquitin-specific peptidase and isopeptidase activities.
ALP22828

Recombinant UCHL3 Protein,Mouse,E. coli,N-His

重组蛋白UCHL3 Protein,Mouse,E. coli,N-His

Q9JKB1(E2-A230) 重组蛋白UCHL3 Protein,Mouse,E. coli,N-His
UCHL3 Protein, a ubiquitin carboxyl-terminal hydrolase, is involved in the regulation of cellular processes and protein degradation. UCHL3 Protein's significance in male fertility and its potential as a therapeutic target in reproductive disorders make it a subject of interest in reproductive medicine.