去泛素化酶通过切割泛素链,逆转蛋白质泛素化修饰,调控蛋白质稳定性、信号转导及细胞周期等关键过程。
| 产品号 | 产品名称 | 蛋白编码 | 图片 |
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| ALP22748 | Q9R0P9(Q2-A223) |
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| UCHL1 Protein, a ubiquitin carboxyl-terminal hydrolase, plays a crucial role in protein degradation and regulation of cellular processes.It is involved in maintaining neuronal integrity and has been linked to neurodegenerative diseases. UCHL1 Protein's potential as a biomarker and therapeutic target in neurodegenerative disorders makes it a subject of intense research in the field of neuroscience. | |||
| ALP22752 | P54578-1(D91-Q494) |
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| USP14 is a proteasome-associated deubiquitinase that regulates ubiquitin dynamics by releasing ubiquitin from proteins marked for degradation. As a reversible proteasome subunit, USP14 ensures ubiquitin replenishment. | |||
| ALP22755 | Q00981(Q2-A223) |
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| The UCHL1 protein is a ubiquitin proteolytic enzyme essential for processing ubiquitin precursors and hydrolyzing ubiquitinated proteins. | |||
| ALP22757 | Q96FW1-1(M1-K271) |
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| OTUB1 protein directly interacts with RNF128, forming a ternary complex with USP8 through OTUB1's binding to the C-terminal UCH catalytic domain of USP8 . | |||
| ALP22758 | P09936(M1-A223) |
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| The UCHL1 protein is a multifunctional deubiquitinase that regulates a variety of cellular processes. It maintains synaptic and cardiac function, modulates inflammatory responses, and influences osteoclastogenesis. | |||
| ALP22770 | Q9UHP3(T2-R1055) |
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| The USP25 protein acts as a deubiquitinating enzyme and plays a key role in the hydrolysis of the ubiquitin moiety conjugated to the substrate. This function enables processing of newly synthesized ubiquitin, recycling of ubiquitin molecules, and editing of polyubiquitin chains, thus preventing proteasomal degradation of substrates. | |||
| ALP22791 | Q93009-1(K208-E560) |
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| The USP7 protein is a hydrolase that deubiquitinates multiple targets, including FOXO4, DEPTOR, KAT5, p53/TP53, MDM2 , ERCC6, DNMT1 , UHRF1 , PTEN , KMT2E/MLL5, and DAXX. It cooperates with DAXX to enhance the E3 ligase activity of MDM2 and promote ubiquitination and degradation of p53/TP53. | |||
| ALP22795 | Q96DC9-1(M1-H234) |
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| OTUB2 is a hydrolase that efficiently removes conjugated ubiquitin from proteins in vitro, implying a crucial role in preventing protein degradation and regulating turnover. Its deubiquitinating activity targets “Lys-11”, “Lys-48” and “Lys-63” linked polyubiquitin chains, with preference for the latter. | |||
| ALP22807 | P15374(M1-A230) |
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| UCHL3 Protein, a ubiquitin carboxyl-terminal hydrolase, is responsible for protein degradation and regulation of cellular processes. | |||
| ALP22811 | P62068(M1-E366) |
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| USP46 protein, as a deubiquitinating enzyme, may participate in behavioral regulation by regulating the effects of GABA. Suggested to mediate deubiquitination of GAD1/GAD67, affecting processes related to GABAergic neurotransmission. | |||
| ALP22819 | Q91Y78(E2-A230) |
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| The UCHL3 protein is a deubiquitinating enzyme (DUB) that complexly controls cellular ubiquitin levels by processing ubiquitin precursors and ubiquitinated proteins. | |||
| ALP22820 | Q9UK80(P2-L565) |
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| USP21 protein is a multifunctional deubiquitinase that plays a key role in the regulation of epigenetic transcriptional repression by deubiquitinating histone H2A. As a coactivator, it relieves the inhibition of dimethylation and trimethylation of histone H3 at "Lys-4", thereby regulating transcription initiation. | |||
| ALP22824 | O94782(M1-L785) |
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| USP1 Protein, Human (His) is the recombinant human-derived USP1 , expressed by E. coli , with N-6*His labeled tag. , | |||
| ALP22825 |
Recombinant USP2 Catalytic Domain Protein,Human,E. coli,N-His |
O75604-1(N259-M605) |
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| USP2 catalytic domain proteins act as hydrolases and target polyubiquitinated proteins such as MDM2 , MDM4, and CCND1. Both isoform 1 and isoform 4 exhibit ubiquitin-specific peptidase and isopeptidase activities. | |||
| ALP22828 | Q9JKB1(E2-A230) |
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| UCHL3 Protein, a ubiquitin carboxyl-terminal hydrolase, is involved in the regulation of cellular processes and protein degradation. UCHL3 Protein's significance in male fertility and its potential as a therapeutic target in reproductive disorders make it a subject of interest in reproductive medicine. | |||