Adamas-life®（阿达玛斯-生命科学）筹建于2017年，是上海泰坦科技股份有限公司（证券代码：688133）旗下自主品牌。致力于开发高标准，高品质，高稳定性，高性价比的生命科学试剂。产品广泛应用于生物医药、临床诊断、食品与环境检测及生命科学基础研究等领域，为科研工作者提供可靠的实验保障与专业服务，助力国内相关产业发展。

产品号	产品名称	蛋白编码
ALP6239	Recombinant Human KEAP1/INRF2 Protein, Human, N-GST&His, Baculovirus-Insect Cells 重组蛋白Human KEAP1/INRF2 Protein, Human, N-GST&His, Baculovirus-Insect Cells	NP_036421.2(Gln2-Cys624)
ALP6239	Kelch-like ECH-associated protein 1, also known as a cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, and INRF2, is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB (POZ) domain, and six Kelch repeats. KEAP1 / INRF2 is broadly expressed, with the highest levels in skeletal muscle. KEAP1 / INRF2 is a key regulator of the NRF2 transcription factor, which transactivates the antioxidant response element (ARE) and upregulates numerous proteins involved in antioxidant defense. Under basal conditions, KEAP1 / INRF2 targets NRF2 for ubiquitination and proteolytic degradation and as such is responsible for the rapid turnover of NRF2. KEAP1 / INRF2 retains NFE2L2 / NRF2 in the cytosol. KEAP1 / INRF2 functions as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. It targets NFE2L2 / NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. KEAP1 / INRF2 may also retain BPTF in the cytosol. It targets PGAM5 for ubiquitination and degradation by the proteasome.
ALP6231	Recombinant Human KEAP1/INRF2 Protein, Human, N-cleavage, Baculovirus-Insect Cells 重组蛋白Human KEAP1/INRF2 Protein, Human, N-cleavage, Baculovirus-Insect Cells	Q14145(Gln2-Cys624)
ALP6231	Kelch-like ECH-associated protein 1, also known as a cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, and INRF2, is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB (POZ) domain, and six Kelch repeats. KEAP1 / INRF2 is broadly expressed, with the highest levels in skeletal muscle. KEAP1 / INRF2 is a key regulator of the NRF2 transcription factor, which transactivates the antioxidant response element (ARE) and upregulates numerous proteins involved in antioxidant defense. Under basal conditions, KEAP1 / INRF2 targets NRF2 for ubiquitination and proteolytic degradation and as such is responsible for the rapid turnover of NRF2. KEAP1 / INRF2 retains NFE2L2 / NRF2 in the cytosol. KEAP1 / INRF2 functions as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. It targets NFE2L2 / NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. KEAP1 / INRF2 may also retain BPTF in the cytosol. It targets PGAM5 for ubiquitination and degradation by the proteasome.
ALP22749	Recombinant KEAP1 Protein,Mouse,E. coli,His,N-SUMO 重组蛋白KEAP1 Protein,Mouse,E. coli,His,N-SUMO	Q9Z2X8(M1-C624)
ALP22749	KEAP1 in the BCR E3 ubiquitin ligase complex complex regulates cellular responses to oxidative stress by ubiquitinating NFE2L2/NRF2. As an oxidative stress sensor, KEAP1 normally promotes NFE2L2/NRF2 degradation.
ALP22759	Recombinant ubiquitin Protein,Human,E. coli,N-His 重组蛋白ubiquitin Protein,Human,E. coli,N-His	P0CG48(M1-G75)
ALP22759	Ubiquitin is a multifunctional protein that can form covalently linked isopeptide bonds in various states, including mono- and polyubiquitin chains. ubiquitin Protein, Human (His) is the recombinant human-derived ubiquitin protein, expressed by E. coli , with N-His labeled tag.
ALP22808	Recombinant USP9X Protein,Human,E. coli,Tag Free 重组蛋白USP9X Protein,Human,E. coli,Tag Free	Q93008(K1554-N1995)
ALP22808	The USP9X protein serves as a deubiquitinase , playing a crucial role in processing ubiquitin precursors and preventing protein degradation. It exhibits specificity in hydrolyzing various polyubiquitin chain linkages, including "Lys-63", "Lys-48", "Lys-29" and "Lys-33".
ALP22817	Recombinant DCUN1D2 Protein,Human,E. coli,N-His 重组蛋白DCUN1D2 Protein,Human,E. coli,N-His	Q6PH85-1(M1-F259)
ALP22817	The DCUN1D2 protein transfers NEDD8 from NEDD8-conjugated E2 to the cullin-RBX complex and regulates SCF-type complex activity.
ALP22827	Recombinant USP9X Protein,Human,E. coli,N-GST 重组蛋白USP9X Protein,Human,E. coli,N-GST	Q93008(K1554-N1995)
ALP22827	The USP9X protein serves as a deubiquitinase , playing a crucial role in processing ubiquitin precursors and preventing protein degradation. It exhibits specificity in hydrolyzing various polyubiquitin chain linkages, including "Lys-63", "Lys-48", "Lys-29" and "Lys-33".

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