生物素标记蛋白利用生物素与链霉亲和素之间极高的亲和力（Kd约10⁻¹⁵ M）进行检测和纯化。生物素通过NHS酯、马来酰亚胺或BirA连接酶定点标记偶联蛋白质，标记后可用于ELISA、Western blot信号放大和链霉亲和素磁珠亲和纯化。定点生物素化相比随机标记能更好保留蛋白活性。
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| 产品号 | 产品名称 | 蛋白编码 | 图片 |
|---|---|---|---|
| ALP8051 |
Biotinylated Human ACE2/ACEH Protein,Human,C-His-Avi,Expi293 重组蛋白Biotinylated Human ACE2/ACEH Protein,Human,C-His-Avi,Expi293 |
Q9BYF1 -1 (Q18-S740) |
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| ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension. The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. | |||
| ALP8056 |
Biotinylated Human ALCAM/CD166 Protein (Primary Amine Labeling) ,Human,C-His,Expi293 重组蛋白Biotinylated Human ALCAM/CD166 Protein (Primary Amine Labeling) ,Human,C-His,Expi293 |
Q13740 (W28-A526) |
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| Brain metastasis (BM) in non-small-cell lung cancer (NSCLC) has a very poor prognosis. Recent studies have demonstrated the importance of cell adhesion molecules in tumor metastasis. Elevated levels of ALCAM expression promote BM formation in NSCLC through increased tumor cell dissemination and interaction with the brain endothelial cells. Therefore, ALCAM could be targeted to reduce the occurrence of BM. | |||
| ALP8060 |
Biotinylated Mouse ALCAM/CD166 Protein,Mouse,C-His-Avi,Expi293 重组蛋白Biotinylated Mouse ALCAM/CD166 Protein,Mouse,C-His-Avi,Expi293 |
Q61490 (Y28-K527) |
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| Brain metastasis (BM) in non-small-cell lung cancer (NSCLC) has a very poor prognosis. Recent studies have demonstrated the importance of cell adhesion molecules in tumor metastasis. Elevated levels of ALCAM expression promote BM formation in NSCLC through increased tumor cell dissemination and interaction with the brain endothelial cells. Therefore, ALCAM could be targeted to reduce the occurrence of BM. | |||
| ALP8066 |
Biotinylated Human ANGPTL2/Angiopoietin-like 2 Protein,Human,C-His-Avi,Expi293 重组蛋白Biotinylated Human ANGPTL2/Angiopoietin-like 2 Protein,Human,C-His-Avi,Expi293 |
Q9UKU9 -1 (T260-H493) |
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| Angiopoietin-like 2 (ANGPTL2) is a proinflammatory protein belonging to the angiopoietin-like family. ANGPTL2 is secreted and detected in the systemic circulation. Different observational clinical studies reported that circulating levels of ANGPTL2 increase significantly in various chronic inflammatory diseases and showed associations between ANGPTL2 levels and diagnosis and/or prognosis of cardiovascular diseases, diabetes, chronic kidney disease, and various types of cancers. | |||
| ALP8082 | P30530 -1 (A26-P449) |
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| Adamas-life ® Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers. | |||
| ALP8094 |
Biotinylated Human B7-2/CD86 Protein,Human,C-His-Avi,Expi293 重组蛋白Biotinylated Human B7-2/CD86 Protein,Human,C-His-Avi,Expi293 |
P42081 -1 (L26-P247) |
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| Adamas-life ® B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimulatory receptors, CD28 and CTLA-4, is essential for the activation and regulation of T cell immunity. B7-1 and B7-2 do not form hetero-oligomers, underscoring the biological relevance of dimeric and monomeric state of B7-1 and B7-2, respectively. | |||
| ALP8103 |
Biotinylated Human BAFFR/TNFRSF13C Protein,Human,C-His-Avi,Expi293 重组蛋白Biotinylated Human BAFFR/TNFRSF13C Protein,Human,C-His-Avi,Expi293 |
Q96RJ3 -1 (S7-A71) |
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| Adamas-life ® BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF13C). These receptors are type III transmembrane proteins that lack a signal peptide. Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL (a proliferation-inducing ligand), BAFF R selectively binds BAFF. | |||
| ALP8154 | Q7Z6A9 -1 (K31-S150) |
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| Adamas-life ® B- and T-lymphocyte attenuator (BTLA; CD272) is a 35 kDa type I transmembrane glycoprotein in the CD28 family of T cell costimulatory molecules. BTLA is a inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. BTLA may interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. | |||
| ALP8169 |
Biotinylated Human CEACAM-5/CD66e Protein,Human,C-His-Avi,Expi293 重组蛋白Biotinylated Human CEACAM-5/CD66e Protein,Human,C-His-Avi,Expi293 |
P06731 -1 (K35-A685) |
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| Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) was identified as a metastatic driver. CEACAM5 overproduction enriched for an epithelial gene expression pattern and facilitated tumor outgrowth at metastatic sites. Tissues from patients with metastatic breast cancer confirmed elevated levels of CEACAM5 in lung metastases relative to breast tumors, and an inverse correlation between CEACAM5 and the mesenchymal marker vimentin was demonstrated. | |||
| ALP8090 |
Recombinant Biotinylated Human B7-1/CD80 Protein,Human,C-His-Avi,Expi293 重组蛋白Biotinylated Human B7-1/CD80 Protein,Human,C-His-Avi,Expi293 |
P33681-1(Val35-Asn242) |
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| Cluster of differentiation 80 (also CD80 and B7-1) is a protein found on dendritic cells, activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 and CTLA-4. | |||
| ALP8195 |
Recombinant Biotinylated Human CD161 Protein,Human,C-His-Avi,Expi293 重组蛋白Biotinylated Human CD161 Protein,Human,C-His-Avi,Expi293 |
Q12918-1(Gln67-Ser225) |
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| CD161 (NKRP1) is a lectin-like receptor present on NK cells and rare T-cell subsets. We have observed CD161 expression in some cases of T-cell prolymphocytic leukemia (T-PLL) and found it to be useful in follow-up and detection of disease after treatment. | |||
| ALP8185 |
Recombinant Biotinylated Human CD155/PVR Protein (Primary Amine Labeling),Human,C-hFc,Expi293 重组蛋白Biotinylated Human CD155/PVR Protein (Primary Amine Labeling),Human,C-hFc,Expi293 |
P15151-1(Trp21-Asn343) |
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| CD155 is a cell surface adhesion molecule functioning in tumor cell migration, invasion, and metastasis, and not surprisingly, is also designated as a common tumor-associated antigen. CD155 is also recognized by NK cells to induce their cytotoxicity. CD155 is also commonly referred to as the "poliovirus receptor," or PVR. | |||
| ALP8180 |
Recombinant Biotinylated Cynomolgus CD161 Protein,Cynomolgus,C-His-Avi,Expi293 重组蛋白Biotinylated Cynomolgus CD161 Protein,Cynomolgus,C-His-Avi,Expi293 |
XP_005570142.1(Gln67-Leu227) |
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| CD161 (NKRP1) is a lectin-like receptor present on NK cells and rare T-cell subsets. We have observed CD161 expression in some cases of T-cell prolymphocytic leukemia (T-PLL) and found it to be useful in follow-up and detection of disease after treatment. | |||
| ALP8172 |
Recombinant Biotinylated Human EpCAM/TROP1 Protein,Human,C-His-Avi,Expi293 重组蛋白Biotinylated Human EpCAM/TROP1 Protein,Human,C-His-Avi,Expi293 |
P16422(Gln24-Lys245) |
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| Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) belongs to the human carcino-embryonic antigen (CEA) family. Numerous lines of studies have indicated that altered expression of CEACAM6 may have a role in carcinogenesis and development. | |||
| ALP8189 |
Recombinant Biotinylated Human IL-2 R beta/CD122 Protein,Human,C-His-Avi,Expi293 重组蛋白Biotinylated Human IL-2 R beta/CD122 Protein,Human,C-His-Avi,Expi293 |
NP_000869(Ala27-Asp239) |
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| IL-2 R beta is a member of the cytokine receptor superfamily. Human IL-2 R beta cDNA encodes a 551 amino acid residue precursor Type I membrane protein with a 26 residue signal peptide, a 214 residue extracellular region, a 25 residue transmembrane region and a 286 residue cytoplasmic domain. Functional IL-2 receptors can exist in two affinity states on cell surfaces, the high affinity complex consisting of heterotrimers of the alpha, beta, and gamma chains, and the intermediate affinity complex comprising heterodimers of the beta and gamma chains. | |||
| ALP8197 |
Recombinant Biotinylated Human CD163 Protein,Human,C-His-Avi,Expi293 重组蛋白Biotinylated Human CD163 Protein,Human,C-His-Avi,Expi293 |
Q86VB7-1(Ser42-Ser1045) |
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| The hemoglobin (Hb) scavenger receptor, CD163, is a macrophage-specific protein and the upregulated expression of this receptor is one of the major changes in the macrophage switch to alternative activated phenotypes in inflammation. Accordingly, a high CD163 expression in macrophages is a characteristic of tissues responding to inflammation. | |||
| ALP8191 |
Recombinant Biotinylated Human IL-2 R gamma/CD132 Protein,Human,C-His-Avi,Expi293 重组蛋白Biotinylated Human IL-2 R gamma/CD132 Protein,Human,C-His-Avi,Expi293 |
P31785-1(Leu23-Asn254) |
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| The gamma chain of the high affinity functional human IL-2 receptor complex belongs to the hematopoietin receptor family. IL-2 R gamma is a 369 amino acid residue protein consisting of a 22 residue signal sequence, a 232 residue extracellular domain, a 29 residue transmembrane domain and an 86 residue cytoplasmic domain. Although IL-2 R gamma by itself does not bind IL-2 with any appreciable affinity, it is required for IL-2 receptor signaling. | |||
| ALP8193 |
Recombinant Biotinylated Human CD155/PVR Protein,Human,C-His-Avi,Expi293 重组蛋白Biotinylated Human CD155/PVR Protein,Human,C-His-Avi,Expi293 |
P15151-1(Trp21-Asn343) |
|
| CD155 is a cell surface adhesion molecule functioning in tumor cell migration, invasion, and metastasis, and not surprisingly, is also designated as a common tumor-associated antigen. CD155 is also recognized by NK cells to induce their cytotoxicity. CD155 is also commonly referred to as the "poliovirus receptor," or PVR. | |||
| ALP8237 |
Recombinant Biotinylated Human CD30/TNFRSF8 Protein,Human,C-His-Avi,Expi293 重组蛋白Biotinylated Human CD30/TNFRSF8 Protein,Human,C-His-Avi,Expi293 |
P28908-1(Phe19-Lys379) |
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| The transmembrane receptor CD30 (TNFRSF8) and its ligand CD30L (CD153, TNFSF8) are members of the tumor necrosis factor (TNF) superfamily and display restricted expression in subpopulations of activated T-and B-cells in nonpathologic conditions. CD30 expression is upregulated in various hematological malignancies, including Reed-Sternberg cells in Hodgkin's disease (HD), anaplastic large cell lymphoma (ALCL) and subsets of Non-Hodgkin's lymphomas (NHLs). | |||
| ALP8240 |
Recombinant Biotinylated Human CD3E&CD3D/CD3 epsilon&CD3 delta Protein,Human,C-hFc-Avi,Expi293 重组蛋白Biotinylated Human CD3E&CD3D/CD3 epsilon&CD3 delta Protein,Human,C-hFc-Avi,Expi293 |
P07766(CD3E)(Asp23-Asp126)&P04234(CD3D)(Phe22-Ala105) |
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| T-cell surface glycoprotein CD3 epsilon&CD3 delta chain, also known as CD3E&CD3D , are single-pass type I membrane proteins.When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. | |||
