细胞黏附分子，介导细胞与细胞或细胞与细胞外基质间黏附的一类膜蛋白，参与组织构建、免疫应答及信号转导。
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| 产品号 | 产品名称 | 蛋白编码 | 图片 |
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| ALP8224 | P16284-1(Gln28-Lys601) |
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| Platelet endothelial cell adhesion molecule 1 (PECAM-1) is an adhesion and signaling receptor that is expressed on endothelial and hematopoietic cells and plays important roles in angiogenesis, vascular permeability, and regulation of cellular responsiveness. | |||
| ALP8322 |
Recombinant Human CDH17/Cadherin 17 Protein,Human,C-His,Expi293 |
Q12864-1(Gln23-Met787) |
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| Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. | |||
| ALP8321 |
Recombinant Cynomolgus CDH17/Cadherin 17 Protein,Cynomolgus,C-His,Expi293 重组蛋白Cynomolgus CDH17/Cadherin 17 Protein,Cynomolgus,C-His,Expi293 |
A0A2K5X8I8(Met1-Met795) |
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| Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. | |||
| ALP8330 |
Recombinant Human CEACAM-1/CD66a Protein,Human,C-His,Expi293 |
P13688-1(Gln35-Gly428) |
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| Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM-1) is the major antigen of the CD66 cluster of granulocyte differentiation antigens. The present study aimed to assess the biological function of CEACAM-1 on the growth of human colorectal cancer (CRC) cells in vitro. | |||
| ALP8324 |
Recombinant Mouse CDH17/Cadherin 17 Protein,Mouse,C-His,Expi293 |
Q9R100(Phe26-Met786) |
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| Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. | |||
| ALP8423 |
Recombinant Human E-Selectin/CD62E Protein,Human,C-His-Avi,Expi293 |
P16581(Trp22-Pro556) |
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| E-Selectin (Endothelial Leukocyte Adhesion Molecule-1, ELAM-1, CD62E), a member of the Selectin family, is a 107 - 115 kDa cell surface glycoprotein. It is transiently expressed on vascular endothelial cells in response to IL-1 beta and TNF-alpha.E-selectin mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis. | |||
| ALP6666 | P97797-1/ Q6P6I8 /BAA13520.1 (K32-N373) |
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| SIRP α/CD172a 蛋白是 CD47 的免疫球蛋白样细胞表面受体，对于结合伴侣易位至质膜至关重要。它在多种细胞过程中发挥关键作用，支持小脑神经元的粘附，促进神经突生长，并促进神经胶质细胞附着。 | |||
| ALP6604 | Q7Z692 -1 (A33-G157) |
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| CEACAM19 蛋白,是重组的 CEACAM19 蛋白，由 HEK293 表达，带有 C-His 标签。 | |||
| ALP8055 | Q13740 (W28-A526) |
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| Brain metastasis (BM) in non-small-cell lung cancer (NSCLC) has a very poor prognosis. Recent studies have demonstrated the importance of cell adhesion molecules in tumor metastasis. Elevated levels of ALCAM expression promote BM formation in NSCLC through increased tumor cell dissemination and interaction with the brain endothelial cells. Therefore, ALCAM could be targeted to reduce the occurrence of BM. | |||
| ALP6640 | BAD26610 (A27-K363) |
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| SIRP- β (Sirpb, CD172b) 是信号调节蛋白 (SIRP) 家族的成员，也属于免疫球蛋白超家族 (IgSF)。SIRP 家族成员是受体型跨膜糖蛋白，Sirpb 被发现与携带免疫受体酪氨酸激活基序的跨膜衔接蛋白 TYROBP/DAP12 相互作用，导致 DAP12 的酪氨酸磷酸化，随后 Syk 被募集到 Sirpb-DAP12 复合体上。Sirpb 还被认为是造血细胞的正调节因子。 | |||
| ALP6651 | Q61330 (Q31-E1013) |
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| Contactin-2/CNTN2 蛋白与跨膜蛋白 CNTNAP2 合作，在 Ranvier 节点处至关重要地组织轴突结构域。这种伙伴关系在近旁区域维持了电压门控钾通道，强调了 Contactin-2 在复杂的分子结构中的关键作用，这对于沿着有髓轴突的有效神经冲动传播至关重要。 | |||
| ALP24816 | XP_005563762.2(Q23-T784) |
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| Cadherin-17 Protein, a member of the calcium-dependent cell adhesion protein family, assumes a crucial role in mediating cellular adhesion. Employing preferential homophilic interactions, Cadherin-17 facilitates self-binding between connecting cells. With its calcium-dependent adhesion properties, Cadherin-17 actively participates in establishing selective connections between cells, influencing the dynamic regulation of cellular interactions and contributing to the overall structural integrity of tissues, particularly in the liver and intestine. | |||
| ALP24821 | AAI15737.1(Q25-N600) |
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| Neuronal cell adhesion molecule (NRCAM) is a member of the immunoglobulin superfamily and a cell adhesion protein. NRCAM is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system while being crucial for the saltatory propagation of action potentials along myelinated axons. NRCAM also plays a general role in cell-cell communication. | |||
| ALP24939 |
Recombinant Integrin alpha 6 beta 4 Protein,Human,HEK293,C-Flag-His |
P23229-3(F24-S1011) |
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| Integrin alpha 6 beta 4 Protein, Human (HEK293, Flag-His) is the recombinant human-derived Integrin alpha 6 beta 4 protein, expressed by HEK293 , with C-His, C-Flag labeled tag., has molecular weight of ~196 kDa. | |||
| ALP25319 | XP_001094728.1(W42-A771) |
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| P-Selectin Protein, Rhesus Macaque (HEK293, His) is a member of the selectin family of cell adhesion molecules . P-selectin mediates leukocyte rolling on stimulated endothelial cells and heterotypic aggregation of activated platelets onto leukocytes. P-selectin mediates heterotypic aggregation of activated platelets to cancer cells and adhesion of cancer cells to stimulated endothelial cells. P-selectin glycoprotein ligand-1 (PSGL-1) is a major ligand for P-selectin. | |||
| ALP25852 | Q96CZ9(F23-T617) |
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| Cadherin-11 is a classical cadherin adhesion molecule that mediates homophilic cell-to-cell adhesion. | |||
| ALP25356 | Q9R0T4(Q24-A713) |
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| Cadherin-1/CD324 protein, a calcium-dependent adhesion molecule, mediates cell processes. It interacts homophilically with other cadherin molecules, sorting and organizing cell types. CDH1 regulates adhesion, mobility, and proliferation of epithelial cells. It serves as an integrin ligand, suppressing invasion and promoting non-amyloidogenic degradation. CDH1 inhibits APP C99 and C83 production. | |||
| ALP25039 | AAH34411.1(E23-G240) |
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| Immunoglobulin superfamily member 11 was originally identified as a member of the immunoglobulin superfamily, and it has been revealed to function as a CAM in a calciumindependent manner. | |||
| ALP25958 |
Recombinant Integrin alpha V beta 6 Protein,Human,HEK293,C-His |
P06756-1(F31-V992) |
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| Integrin alpha V beta 6 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 6 protein, expressed by HEK293 , with C-His labeled tag. Integrin alpha V beta 6 Protein, Human (HEK293, His), has molecular weight of ~130 & 95 KDa, respectively. | |||
| ALP25500 | Q8NFZ8(P21-Y323) |
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| CADM4/IGSF4C Protein is crucial for calcium- and magnesium-independent cell-cell adhesion, actively mediating cellular interactions. Apart from its adhesive role, it is speculated to act as a tumor suppressor, hinting at a potential regulatory role in cell growth and tumorigenic processes. The dual attributes of mediating adhesion and potentially suppressing tumors highlight the multifaceted nature of CADM4/IGSF4C in cellular processes. | |||
