G蛋白偶联受体是一类跨膜蛋白受体，通过与G蛋白相互作用，将细胞外信号转化为细胞内信号，调控多种生理过程。
| 产品号 | 产品名称 | 蛋白编码 | 图片 |
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| ALP24797 | Q8BKG4/NP_780493.1(I22-G162) |
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| Frizzled-10/CD350 protein is a receptor for Wnt proteins that functions in the canonical Wnt/β-catenin pathway, activating disheveled proteins, inhibiting GSK-3 kinase, and triggering Wnt target gene activation. Secondary signaling pathways involve PKC and calcium flux. | |||
| ALP24798 | NP_009128.1(I21-G161) |
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| The Frizzled-10/CD350 gene is a member of the Frizzled gene family, encoding a 7-transmembrane domain protein that acts as a receptor for the Wingless-type MMTV integration site family signaling protein. Most Frizzled receptors, including Frizzled-10/CD350 , are involved in cell signaling, specifically the β-catenin classical pathway. | |||
| ALP24811 | Q96CH1(M1-A333) |
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| GPR146 operates as an orphan receptor . | |||
| ALP24871 |
Recombinant EDNRB/Endothelin R Type B Protein,Human,HEK293,C-His |
P24530/NP_000106.1(E27-K101) |
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| EDNRB/Endothelin R Type B Protein, a non-specific receptor for endothelin 1, 2, and 3, activates a phosphatidylinositol-calcium second messenger system through G proteins. This mechanism underscores its pivotal role in mediating cellular responses initiated by endothelin neuropeptides, emphasizing the versatility of EDNRB in transducing signals for various physiological processes. | |||
| ALP24876 | P47871(A26-K136) |
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| The GCGR protein is a glucagon G protein-coupled receptor that is critical in blood glucose regulation and actively controls hepatic glucose production. It promotes glycogen hydrolysis and gluconeogenesis, which are critical for the fasting response. | |||
| ALP25031 | P25101(D21-K80) |
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| EDNRA Protein, a receptor for endothelin-1, activates a phosphatidylinositol-calcium second messenger system through association with G proteins. Its binding affinities follow the order: ET1 > ET2 >> ET3. Additionally, EDNRA interacts with HDAC7 and KAT5. | |||
| ALP25960 | Q9Y653-2/NP_958933.1(R26-V342) |
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| GPR56, a cell adhesion receptor, mediates cell-matrix adhesion in developing neurons and hematopoietic stem cells. It acts as a receptor for collagen III (COL3A1), influencing cortical development and hematopoietic stem cell maintenance. Additionally, GPR56 plays a pivotal role in cancer progression by inhibiting angiogenesis via PRKCA-mediated signaling and is essential for testis development. | |||
| ALP25452 | O60353-1/NP_003497.2(H19-V153) |
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| Frizzled-6 is a Wnt receptor that complexly activates signaling pathways that converge primarily on the β-catenin canonical pathway. This triggers disorganized protein activation, GSK-3 kinase inhibition, nuclear β-catenin accumulation, and Wnt target gene activation. | |||
| ALP25170 | Q6QNK2-1/NP_942122.2(V26-S570) |
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| GPR133 Protein, an orphan receptor , signals through the G(s)-alpha family of G-proteins, as indicated by studies. Its protumorigenic function, particularly in glioblastoma, suggests a potential role in tumorigenesis-associated pathological processes. | |||
| ALP25172 | P30542(M1-D326) |
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| ADORA1 Protein, a receptor for adenosine, inhibits adenylyl cyclase through G proteins, modulating cellular activity. | |||
| ALP25298 | Q14332(Q24-P190) |
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| FZD2 protein is a receptor for Wnt proteins that activates the β-catenin classical pathway, inhibits GSK-3 kinase and triggers Wnt target genes. FZD2 and some family members possess a secondary PKC-calcium pathway, but its integration with the classical pathway remains unclear. | |||
| ALP26076 | O75084/NP_003498(Q33-L185) |
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| GIP Protein is a protein involved in the regulation of glucose homeostasis and insulin secretion. It plays a crucial role in modulating pancreatic beta-cell function and glucose metabolism. Dysregulation of GIP Protein has been associated with various diseases, including type 2 diabetes and obesity. Targeting GIP Protein may offer potential therapeutic interventions in these conditions by improving glucose regulation and insulin sensitivity. | |||
| ALP25851 | Q8IZF4(E22-G184) |
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| GPR114, an adhesion G protein-coupled receptor (GPCR), crucially activates the adenylate cyclase pathway by coupling with G(s) subunit alpha. Isoform 1, displaying constitutive activity, elevates basal cyclic AMP (cAMP) levels and responds to mechanical stimulation, emphasizing GPR114's functional significance in intracellular signaling cascades and its role in cellular responses to mechanical cues. | |||
| ALP25035 | P34972(M1-C360) |
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| CNR2 Protein, a heterotrimeric G protein-coupled receptor, crucially inhibits adenylate cyclase , mediating functions in inflammatory responses, nociceptive transmission, and bone homeostasis. Its modulation of cellular signaling underscores its significance in physiological processes, positioning CNR2 Protein as a key regulator in inflammatory, sensory mechanisms, and bone equilibrium. | |||
| ALP25177 | P30988(A25-V154) |
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| Calcitonin R protein, a receptor for calcitonin , utilizes G proteins to activate adenylyl cyclase. Despite being sensitive to cholera toxin, it exhibits limited coupling to G proteins, leading to the inability to effectively activate adenylyl cyclase. Notably, following ligand binding, Calcitonin R does not undergo the conventional process of receptor internalization. | |||
| ALP25549 | Q9NPG1(H23-A666) |
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| FZD3 is a Wnt receptor that primarily activates the β-catenin canonical pathway, involving disheveled protein, GSK-3 kinase inhibition, nuclear β-catenin accumulation, and Wnt target gene induction. | |||
| ALP25685 | Q9EQD0(A27-P167) |
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| Frizzled-5 is a Wnt receptor that activates canonical Wnt/β-catenin signaling through WNT2, WNT10B, and WNT5A. It participates in a potential second pathway involving PKC and calcium flux, affecting Wnt-mediated inactivation of GSK-3 kinase. | |||
| ALP26165 | Q9R216(L24-D186) |
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| Frizzled-9 is a WNT2 receptor that is critical for activation of the β-catenin pathway, involved in Disheveled protein activation, GSK-3 kinase inhibition, nuclear β-catenin accumulation, and Wnt target gene activation. In addition to classical signaling, it negatively regulates acetylcholine receptor clustering in neuromuscular junction assembly and affects the viability of neural progenitor cells by regulating the cell cycle. | |||
| ALP6256 | NP_003459.2(Ala27-Pro167) |
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| Wnt signaling is involved in a variety of embryonic development processes of nonvertebrates and vertebrates, where it determines cell motility, cell polarity, differentiation, proliferation and apoptosis, as well as formation of neural synapses. Various homologs of the Wingless protein, termed WNT factors, represent key mediators and act through a receptor complex comprised of members of the Frizzled and low density lipoprotein-related receptors (LRP). 19 WNTs, 1 Frizzled, and 2 LRP proteins have been identified. Frizzled is a family of G protein-coupled receptor proteins consisting of a divergent signal peptide, a highly conserved extracellular cysteine-rich domain (CRD), a variable-length linker region, a seven-pass transmembrane domain, and a variable-length C-terminal tail.Frizzled 5 (FZD5) is believed to be the receptor for the Wnt5A ligand, and also interactions with Wnt1B, Wnt2B, and Wnt 7A functionally. Recent studies of WNT5A/Frizzled-5 signaling have revealed an unexpected and novel role in orchestrating adaptive immunity in response to microbial stimulation. In addition, FZD5 is also implicated in the survival of mature neurons in the parafascicular nucleus of the thalamus. | |||
| ALP6728 |
Recombinant Cynomolgus GLP1R N-ECD, Cynomolgus, HEK293, C-6His |
F8V479（R24-L144） |
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| GLP-1 receptor (GLP-1R) is a pivotal target in the treatment of type 2 diabetes and obesity due to its role in enhancing insulin secretion, inhibiting glucagon release, and promoting satiety. As a member of the incretin family, GLP-1 is secreted from the intestines in response to food intake, stimulating glucose-dependent insulin secretion from pancreatic beta cells. The therapeutic potential of GLP-1R agonists, such as exenatide and liraglutide, has led to significant advancements in diabetes management, demonstrating improved glycemic control and weight loss. However, challenges such as the rapid degradation of native GLP-1 necessitate the development of stable and effective GLP-1R agonists. Research into recombinant GLP-1R proteins aims to enhance understanding of the | |||
