唾液酸结合免疫球蛋白样凝集素，主要表达于免疫细胞表面，通过识别含唾液酸的糖链调节免疫应答，在炎症和自身免疫中起关键作用。
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| 产品号 | 产品名称 | 蛋白编码 | 图片 |
|---|---|---|---|
| ALP6708 | Q6PJ50 /AAH23280 (Q20-F355) |
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| Siglec-E 蛋白是人 Siglec-9 的小鼠直系同源物，是一种关键的免疫抑制检查点分子。Siglec-E 与 CD36 相互作用，抑制参与修饰 LDL 摄取的下游 VAV 信号传导，进而延缓动脉粥样硬化。内源性诱导型 Siglec-E 在缺血性中风后发挥重要的抗炎和神经保护作用。 | |||
| ALP8981 |
Recombinant Cynomolgus Siglec-15/CD33L3 Protein,Cynomolgus,C-His-Avi,Expi293 重组蛋白Cynomolgus Siglec-15/CD33L3 Protein,Cynomolgus,C-His-Avi,Expi293 |
XP_005586866.2(Met60-Thr322) |
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| Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates. | |||
| ALP8985 |
Recombinant Human Siglec-5/CD170 Protein,Human,C-hFc,Expi293 |
O15389(Glu17-Thr434) |
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| Interactions between endothelial selectins and the leukocyte counter-receptor PSGL1 mediates leukocyte recruitment to inflammation sites. PSGL1 is highly sialylated, making it a potential ligand for Siglec-5, a leukocyte-receptor that recognizes sialic acid structures. Binding assays using soluble Siglec-5 variants (sSiglec-5/C4BP and sSiglec-5/Fc) revealed a dose- and calcium-dependent binding to PSGL1. | |||
| ALP8986 | Q9NYZ4(Met17-Ala363) |
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| Siglec-8, also known as SAF, is an approximately 75 kDa transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-8 consists of a 347 amino acid (aa) extracellular domain (ECD) with three Ig-like domains.Putative adhesion molecule that mediates sialic-acid dependent binding to red blood cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. | |||
| ALP8987 | Q96LC7-1(Met17-Thr546) |
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| Siglec-10 is a ligand for CD52, the target of the therapeutic monoclonal antibody Alemtuzumab. It is also reported to bind to Vascular adhesion protein 1 (VAP-1) and to the co-stimulatory molecule CD24 also known as HSA (Heat-stable antigen).Siglecs (sialic acid binding Ig-like lectins) are I-type lectins that belong to the immunoglobulin superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by a varying number of Ig-like C2-type domains. Siglecs 5-11 constitute the CD33/Siglec-3 related group, and are differentially expressed in the hematopoietic system. | |||
| ALP8988 |
Recombinant Human Siglec-15/CD33L3 Protein,Human,C-hFc,Expi293 |
Q6ZMC9-1(Lys24-Gly260) |
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| Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates. | |||
| ALP8991 | P20916(Gly20-Pro516) |
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| Siglec-4a, also known as Myelin-Associated Glycoprotein (MAG), is a type I transmembrane glycoprotein belonging to the Siglec family, a subgroup of the Ig superfamily. Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2. | |||
| ALP8992 | Q9NYZ4(Met17-Ala363) |
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| Siglec-8, also known as SAF, is an approximately 75 kDa transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-8 consists of a 347 amino acid (aa) extracellular domain (ECD) with three Ig-like domains.Putative adhesion molecule that mediates sialic-acid dependent binding to red blood cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. | |||
| ALP8996 |
Recombinant Human Siglec-15/CD33L3 Protein,Human,C-His-Avi,Expi293 |
Q6ZMC9(Phe20-Thr263) |
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| Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates.. | |||
| ALP8998 | Q96LC7-1(Met17-Thr546) |
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| Siglec-10 is a ligand for CD52, the target of the therapeutic monoclonal antibody Alemtuzumab. It is also reported to bind to Vascular adhesion protein 1 (VAP-1) and to the co-stimulatory molecule CD24 also known as HSA (Heat-stable antigen).Siglecs (sialic acid binding Ig-like lectins) are I-type lectins that belong to the immunoglobulin superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by a varying number of Ig-like C2-type domains. Siglecs 5-11 constitute the CD33/Siglec-3 related group, and are differentially expressed in the hematopoietic system. | |||
| ALP9000 |
Recombinant Mouse Siglec-15/CD33L3 Protein,Mouse,C-His,Expi293 |
A7E1W8-1(Arg24-Thr262) |
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| Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates. | |||
| ALP9761 |
Recombinant Human Siglec-10 (R119A) Protein,Human,C-His-Avi,Expi293 |
Q96LC7-1(Met17-Thr546) |
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| Siglec-10 is a ligand for CD52, the target of the therapeutic monoclonal antibody Alemtuzumab. It is also reported to bind to Vascular adhesion protein 1 (VAP-1) and to the co-stimulatory molecule CD24 also known as HSA (Heat-stable antigen).Siglecs (sialic acid binding Ig-like lectins) are I-type lectins that belong to the immunoglobulin superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by a varying number of Ig-like C2-type domains. Siglecs 5-11 constitute the CD33/Siglec-3 related group, and are differentially expressed in the hematopoietic system. | |||
| ALP9615 | P20916(Gly20-Pro516) |
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| Siglec-4a, also known as Myelin-Associated Glycoprotein (MAG), is a type I transmembrane glycoprotein belonging to the Siglec family, a subgroup of the Ig superfamily. Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2. | |||
| ALP6233 | NP_998767.1(Phe20-Gly260) |
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| Recombinant Human SIGLEC15 Protein, expressed in HEK293 cells with C-terminal His tag. | |||
| ALP26013 | AAK72907(N17-H543, E84A, K145Q) |
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| Siglec-11 Protein, Human (E84A, K145Q, CHO, hFc) is the recombinant human-derived Siglec-11 protein, expressed by CHO , with C-hFc labeled tag. | |||
| ALP25411 | P20917(G20-P516) |
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| MAG/Siglec-4a protein mediates myelin cell-neuron interactions by binding to gangliosides, RTN4R, and RTN4RL2.It maintains normal axonal myelination and protects motor neurons from apoptosis following injury. | |||
| ALP25591 | P20917(G20-P516) |
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| MAG/Siglec-4a protein mediates myelin cell-neuron interactions by binding to gangliosides, RTN4R, and RTN4RL2. It maintains normal axonal myelination and protects motor neurons from apoptosis following injury. | |||
| ALP25080 | Q80ZE3(M19-K543) |
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| Siglec-10 protein is an adhesion molecule that mediates sialic acid-dependent cell binding, preferentially selecting α-2,3- or α-2,6-linked sialic acid. Its sialic acid recognition site may be masked through cis interactions. | |||
| ALP25081 | Q920G3(D18-T437) |
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| Siglec-F Protein, a putative adhesion molecule, crucially mediates sialic-acid dependent binding to cells with a preferential affinity for alpha-2,3-linked sialic acid. Notably, its sialic acid recognition site may be concealed through cis interactions with sialic acids on the same cell surface. | |||
| ALP23354 |
Recombinant Biotinylated Siglec-5 Protein,Human,HEK293,C-His-Avi |
O15389(E17-T434) |
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| Siglec-5 Protein, a putative adhesion molecule, participates in sialic-acid dependent cellular binding, showing equal affinity for alpha-2,3-linked and alpha-2,6-linked sialic acid. Its sialic acid recognition site may be masked through cis interactions with sialic acids on the same cell surface. | |||
