杀伤细胞免疫球蛋白样受体，主要表达于NK细胞表面，通过识别MHC-I类分子调控NK细胞活性，在免疫监视和自身免疫中起关键作用。
| 产品号 | 产品名称 | 蛋白编码 | 图片 |
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| ALP25882 | Q8N109/NP_065396.1(H22-H240) |
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| KIR2DL5/CD158f, present on NK cells, acts as a receptor for HLA-C alleles. Its inhibitory function finely tunes NK cell activity, preventing cell lysis by interacting with specific HLA-C molecules. This dynamic engagement contributes to the nuanced balance of inhibitory signals in the immune system, regulating NK cell responses to potential targets. | |||
| ALP25349 | Q14952(H22-H245) |
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| KIR2DS3 , present on NK cells, selectively recognizes HLA-C alleles. In contrast to inhibitory KIRs, KIR2DS3 lacks inhibitory effects on NK cell activity. Its role is likely in activating or modulating NK cell functions, contributing to the nuanced balance of signals regulating the immune response. | |||
| ALP25448 | Q14954(H22-H245) |
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| KIR2DS1 , on NK cells, acts as a receptor for specific HLA-C alleles, like w6, without inhibiting NK cell activity. Interacting with the adapter protein TYROBP/DAP12, their collaboration enhances KIR2DS1 stability at the cell surface. This dynamic interplay highlights the intricate regulatory mechanisms associated with KIR2DS1 , contributing to the modulation of NK cell responses. | |||
| ALP8703 | P43626(His22-Arg242) |
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| KIR2DL1 (2DL1, formerly NKAT1, designated CD158a) is a 348 amino acid (aa) type I transmembrane glycoprotein that belongs to the human killer cell Ig-like receptor (KIR) family.KIR2DL1 is a receptor on natural killer (NK) cells for some HLA-C alleles such as w4 and w6. Inhibits the activity of NK cells thus preventing cell lysis. | |||
| ALP8705 | P43627(His22-His245) |
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| KIR2DL2 (2DL2, formerly NKAT6, designated CD158b) is a 348 amino acid (aa) type I transmembrane glycoprotein that belongs to the human killer cell Ig‑like receptor (KIR) family. KIRs are expressed on human CD56dim NK cells and T cell subsets, and regulate effector functions in the innate immune system.KIR2DL2 is receptor on natural killer (NK) cells for HLA-Cw1, 3, 7, and 8 allotypes. Inhibits the activity of NK cells thus preventing cell lysis. | |||
| ALP8707 | P43628(His22-His245) |
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| KIR2DL3 (2DL3, formerly NKAT2, designated CD158b2) is a 341 amino acid (aa) type I transmembrane glycoprotein that belongs to the human killer cell Ig‑like receptor (KIR) family of molecules. KIRs are expressed on human CD56dim NK cells and T cell subsets, and regulate effector functions in the innate immune system.KIR2DL3 is a receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis. | |||
| ALP8709 | NP_065396(His22-His240) |
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| A recently developed anti-KIR2DL5 (CD158f) antibody has demonstrated KIR2DL5 expression on the surface of NK and T lymphocytes, making it the last functional KIR identified in the human genome. KIR2DL5 belongs to an ancestral lineage of KIR with Ig-like domains of the D0-D2 type, of which KIR2DL4, an HLA-G receptor, is the only other human member. | |||
| ALP8713 | Q8N743(Glu26-Leu322) |
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| Killer-cell immunoglobulin-like receptor (KIR) 3DL3 is a framework gene present in all human KIR haplotypes.KIR3DL3 has been shown to be constitutively expressed at a low RNA level in peripheral blood mononuclear cell (PBMC) and decidual natural kill (NK) cells. | |||
| ALP22964 | P43626-1/NP_055033.2(H22-H245) |
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| KIR2DL1, found on NK cells, serves as a receptor for specific HLA-C alleles, inhibiting NK cell activity to prevent cell lysis . This regulatory function involves interactions with ARRB2 and, additionally, engages PTPN6 and PTPN11. The interaction's enhancement by ARRB2 underscores KIR2DL1's role in complex signaling networks that modulate NK cell function. | |||
| ALP23444 |
Recombinant Biotinylated KIR3DL3/CD158z Protein,Human,HEK293,C-His-Avi 重组蛋白Biotinylated KIR3DL3/CD158z Protein,Human,HEK293,C-His-Avi |
Q8N743(E26-L322) |
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| KIR3DL3/CD158z, on natural killer cells, potentially inhibits NK cell activity, contributing to the prevention of cell lysis . This regulatory role underscores the significance of KIR3DL3 in modulating NK cell functions and maintaining immune homeostasis. | |||
| ALP23964 | Q8N743/NP_703144.2(Q26-L322) |
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| KIR3DL3/CD158z, on natural killer cells, potentially inhibits NK cell activity, contributing to the prevention of cell lysis . This regulatory role underscores the significance of KIR3DL3 in modulating NK cell functions and maintaining immune homeostasis. | |||
| ALP24116 | ADY38409.1(W22-H242) |
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| CD158d/KIR2DL4 Protein is an NK cell-activating receptor with inhibitory potential. | |||
