补体系统第五组分，在免疫防御中通过经典或替代途径被激活，裂解后形成C5a和C5b，分别介导炎症反应和膜攻击复合物的形成。
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| 产品号 | 产品名称 | 蛋白编码 | 图片 |
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| ALP6657 |
Human Complement C5/C5a Protein, Human, E.coli, Tag Free 重组蛋白Human Complement C5/C5a Protein, Human, E.coli, Tag Free |
P01031 (T678-R751) |
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| Complement C5/C5a 蛋白, Human 是一种重组人补体 C5a。C5a 是一种 74 个氨基酸的糖蛋白，由 C 系统激活产生。补体 C5 在补体激活的末端被蛋白质水解，产生促炎性 C5a 和膜攻击复合物核因子 C5b。C5a 是补体激活产生的炎症介质，积极调节免疫防御的各个环节，包括 Toll 样受体 4 (TLR4) 信号。 | |||
| ALP9282 | P01031-1(Gln19-Cys1676) |
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| Complement component 5 (C5) is an essential factor of the defensive complement system in all vertebrates.C5 plays a major role in complement activation; C5 convertase cleaves C5 into the pro-inflammatory C5a, and C5b, the nidus for the formation of the lytic membrane attack complex. | |||
| ALP6218 |
Recombinant Human Complement C5 Protein, Human, N-Flag&C-His, HEK293 重组蛋白Human Complement C5 Protein, Human, N-Flag&C-His, HEK293 |
NP_001726.2(Gln19-Cys1676) |
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| C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathways of complement activation. The structure of C5a includes a core region consisting of four, anti-parallel alpha-helices held together by three disulfide linkages and a structured C-terminal tail, and C5a is rapidly metabolised by carboxypeptidase B to a 73 amino acid low activity form, C5a des-Arg. C5a is an extremely potent proinflammatory mediator, as well as a potent chemotactic factor for neutrophils and other leukocytes. It causes histamine release, increases in vascular permeability, induces several cytokines production from leukocytes, enhances neutrophil-endothelial cell adhesion, and augments the humoral and cell-mediated immune response. Acting via a classical G protein-coupled receptor, CD88, C5a and C5adesArg exert a number of effects essential to the innate immune response, while their actions at the more recently discovered non-G protein-coupled receptor, C5L2 (or GPR77), remain unclear. C5a is a strong chemoattractant and is involved in the recruitment of inflammatory cells such as neutrophils, eosinophils, monocytes, and T lymphocytes, in activation of phagocytic cells and release of granule-based enzymes and generation of oxidants, all of which may contribute to innate immune functions or tissue damage. Accordingly, the anaphylatoxin C5a is implicated in a variety of diseases such as rheumatoid arthritis, systemic lupus erythematosus, reperfusion injury, Alzheimer's disease, and sepsis. | |||
| ALP22519 | P06684(N679-R755) |
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| C5a is a potent pro-inflammatory mediator and acts as an essential part of the innate immune response. | |||
| ALP22559 | P06684(N679-R755) |
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| C5a is a potent pro-inflammatory mediator and acts as an essential part of the innate immune response. | |||
| ALP22565 |
Recombinant Complement C5a Protein,Cynomolgus,E. coli,Tag Free |
XP_015292262.1(M678-R751) |
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| Complement C5 is activated by C5 convertase, inducing C5-C9 assembly to form the membrane attack complex. The transient C6 binding site on C5b is critical for the formation of the cleavage complex. | |||
